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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Struktur
944261-79-4
CAS-Nr.
944261-79-4
Englisch Name:
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide
Synonyma:
brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
CBNumber:
CB31471262
Summenformel:
C19H16ClNO4
Molgewicht:
357.79
MOL-Datei:
944261-79-4.mol
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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Eigenschaften

Schmelzpunkt:
128-130?C
Siedepunkt:
450.6±45.0 °C(Predicted)
Dichte
1.294±0.06 g/cm3(Predicted)
storage temp. 
room temp
Löslichkeit
DMSO: >10mg/mL
pka
11.72±0.70(Predicted)
Aggregatzustand
powder
Farbe
white to tan
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemische Eigenschaften

White Solid

Allgemeine Beschreibung

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biologische Aktivität

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 118)Lieferanten
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
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 trendseenbio@gmail.com China 11681 58

944261-79-4()Verwandte Suche:

Procainamidhydrochlorid N-(4-Chlorphenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamidmonohydrochlorid Tetracainhydrochlorid Aconitin 4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Tetrodotoxin [R-(E)]-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-on
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
    -dimethoxyphenylamide
  • 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
  • A 803467
  • 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-
  • 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide
  • 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)-
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
  • A-803467, >=99%
  • A803467;A 803467
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt
  • brgt
  • -dimethoxyphenylamide
  • A-803467, >98%
  • CS-374
  • [3H]-A-803467
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP
  • 944261-79-4
  • Ion Channels
  • Inhibitors
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sodium channel
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