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(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol Produkt Beschreibung

L(-)-Borneol Struktur
464-45-9
CAS-Nr.
464-45-9
Bezeichnung:
(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol
Englisch Name:
L(-)-Borneol
Synonyma:
bornel;Linderol;FEMA 2157;L-BORNEOL;Mei Slice;2-bornanol;ngaicamphor;2-Camphanol;Bornan-2-ol;Ngai camphor
CBNumber:
CB3219500
Summenformel:
C10H18O
Molgewicht:
154.25
MOL-Datei:
464-45-9.mol

(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol Eigenschaften

Schmelzpunkt:
206-209 °C
alpha 
-36.2 º (c=5, C2H5OH)
Siedepunkt:
210 °C(lit.)
Dichte
0.8389 (rough estimate)
Dampfdichte
5.31 (vs air)
Dampfdruck
33.5 mm Hg ( 25 °C)
Brechungsindex
-36 ° (C=5, EtOH)
FEMA 
2157 | BORNEOL
Flammpunkt:
150 °F
storage temp. 
Store below +30°C.
pka
15.36±0.60(Predicted)
Aggregatzustand
Crystalline Powder or Crystals
Farbe
White to light yellow
Optische Aktivität
[α]20/D 35.3°, c = 5 in ethanol
Wasserlöslichkeit
INSOLUBLE
Merck 
14,1338
BRN 
3587558
CAS Datenbank
464-45-9(CAS DataBase Reference)
NIST chemische Informationen
Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)-(464-45-9)
EPA chemische Informationen
(-)-Borneol (464-45-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,Xi
R-Sätze: 11-43
S-Sätze: 16-36/37
RIDADR  UN 1312 4.1/PG 3
WGK Germany  2
RTECS-Nr. DT5095000
TSCA  Yes
HazardClass  4.1
PackingGroup  III
HS Code  29061900
Toxizität LD50 orally in Rabbit: 5800 mg/kg
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H228 Entzündbarer Feststoff. Entzündbare Feststoffe Kategorie 1 Achtung
Warnung
P210, P240,P241, P280, P370+P378
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P240 Behälter und zu befüllende Anlage erden.
P241 Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Geräte verwenden.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P370+P378 Bei Brand: zum Löschen verwenden.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R11:Leichtentzündlich.
R43:Sensibilisierung durch Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Aussehen Eigenschaften

C10H18O; L-Borneol. Farbloses Pulver.

Gefahren für Mensch und Umwelt

Brennbar.
LD50 (oral, Ratte): 5800 mg/kg

Schutzmaßnahmen und Verhaltensregeln

Schutzhandschuhe als kurzzeitiger Staubschutz.

Verhalten im Gefahrfall

Trocken aufnehmen.
Kohlendioxid, Wasser.
Brennbar. Im Brandfall können gefährliche Gase freigesetzt werden.

Erste Hilfe

Nach Hautkontakt: Mit reichlich wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 15 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Reichlich Wasser trinken. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung

Gelöst in z.B. Ethanol als halogenfreie, organische Lösemittelabfälle.

Beschreibung

Borneol is an analgetic, antibacterial, and resuscitation-inducing norborneol derived from fresh branches and leaves of Cinnamomum camphora (L.) Presl. Far more than 2000?years ago, it has been introduced to China . In China, it has been firstly recorded in Ming Yi Bie Lu and then included in Tang Ben Cao. It was recorded in history that borneol was derived from Dryobalanops camphora gaertner and then precipitated from the resin to form the natural crystal compound or distilled from the trunk and cooled down to form the crystal compound, which is certified from Indonesia. In China, the natural borneol mainly relied on imports. In recent years, it was extracted from the Lauraceae plants, including Cinnamomum camphora, Cinnamomum longepaniculatum, and Cinnamomum burmannii, which greatlyincreases the resources of natural borneol for China. Cinnamomum camphora is mainly distributed in Jiangxi and Fujian provinces with 81.78% of borneol. Cinnamomum longepaniculatum is mainly distributed in Hunan and Sichuan provinces with 77.57% of borneol. Cinnamomum burmannii is mainly distributed in Yunnan and Guangxi provinces with 70.81% of borneol. Among them, Cinnamomum camphora contains more borneol than the other two types .

Chemische Eigenschaften

white to light yellow crystalline powder or

Physikalische Eigenschaften

Appearance: colorless to white lumps. Odor: pungent, camphor-like. Density:1.011?g/ cm3 (20?°C). Melting point: 208?°C (406?°F; 481?K). Boiling point: 213?°C (415?°F; 486?K). Solubility: slightly soluble in water (D-form), soluble in chloroform, ethanol, acetone, ether, benzene, toluene, decalin, and tetralin. Flash point: 65? °C (149?°F; 338?K). It’s stable under sealed condition while volatile in the air.

History

Borneol has been widely used worldwide. It has been systematically studied since 1803 in Dutch literature. This might be because borneol was originated from Indonesia which had been the colony of the Netherlands since the seventeenth century. Stockman reviewed the borneol systematically and conducted the preliminary pharmacological experiments. The current pharmacological studies of borneol focus on crossing blood-brain barrier and its mechanism, as well as promoting the penetration of blood-brain barrier after compatibility with other drugs, which has been started by Qizhong Mo in Shanghai Institute of Materia Medica, Chinese Academy of Sciences since 1982 . Qide Wu et al. synthesized a series of ester derivatives of natural borneol and studied its biological properties. It was found that (+) – 4-methoxybenzoic acid borneol ester had a significant effect on the opening of the blood-brain barrier and was less toxic than borneol . Because of the unique chemical structure of borneol and relatively low molecular weight, borneol is often modified to observe whether the drug has such pharmacological effects of antitumor, increasing the penetration of blood-brain barrier, antibacterial, antioxidant, and others. Up to date, there is no druggability report based on borneol modification.

Indications

The main efficacy of borneol is to induce resuscitation (with aromatic stimulation), clear stagnated fire (fever feeling), remove nebula for improving eyesight, and relieve swelling and pain. The indications of borneol are sore throat, aphthous, red eyes, purulent ear discharge, convulsions, febrile delirium, sudden faint due to qi depression, stroke, and coma. In Chinese traditional medicine, the borneol is often used as an envoy drug and combined with other drugs but is not used as a single medicine with the inexact efficacy

Pharmakologie

The main pharmacological effects of borneol include anti-inflammatory, antibacterial, central nervous system, and antifertility effects . Guangchi Jiang found that intraperitoneal injection of borneol at 3.5 mL/kg can significantly inhibit foot swelling caused by egg white in rats. Borneol can inhibit and kill Staphylococcus aureus, B-type Streptococcus, and other five common cells with the minimum inhibitory concentration (MIC) of 1.0–2.0% and the lowest bactericidal concentration (MFC) of 1.5–2.0%. There was significant odinopoeia effect on the late pregnant mice after given 112 mg/kg borneol. Qide Liu et al. found that 10% borneol paraffin oil at the dose of 1 mg/kg by oral gavage can significantly increase the concentration of gentamicin in rat brain tissue, suggesting that borneol can change the blood-brain barrier permeability. The current mechanisms of anti-inflammatory effects include inhibition of inflammatory factors of interleukin-1β, tumor necrosis factor-α, and cell adhesion molecule-1 expression. The mechanisms of central nervous system effects are involved in inhibiting p-glycoprotein, opening the intercellular tight junction, increasing the number of pinocytotic vesicles, and improving the phospholipid molecule arrangement of epithelial cell membrane. In addition, borneol also affects the level of nitric oxide and inhibits the elevation of Ca2+ concentration.

Clinical Use

As a traditional Chinese medicine, borneol is commonly used as envoy drugs in the compatibility of traditional Chinese medicine. On behalf of combination drugs such as Danshen dripping pills, Niu Huang Jie Du pills, and watermelon cream, its effect is significant because of its special aromatic smell. Borneol with a certain irritation, oral administration may cause the gastrointestinal discomforts, severely causes vomiting and other adverse reactions.

Sicherheitsprofil

Mddly toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.

(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 156)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
+86-371-86658258
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
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BOC Sciences
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Chongqing Chemdad Co., Ltd
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Shanghai Standard Technology Co., Ltd.
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+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
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CONIER CHEM AND PHARMA LIMITED
86-18523575427
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Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4149 58

464-45-9((1S-endo)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol)Verwandte Suche:


  • L(-)-Borneol, 97% 100GR
  • (-)-Borneol, 97+%
  • Bornencamphor
  • Borneol, (1S,2R,4S)-(-)-
  • endo-2-Hy-droxycamphane
  • l-2-Bornanol
  • l-2-Camphanol
  • Linderol
  • Malayancam-phor
  • Ngai camphor
  • ngaicamphor
  • syntheticd-borneol
  • CAMPHOL-(+)-BORNOL
  • BORNEO CAMPHOR
  • BORNEOL FLAKES
  • BORNYL ALCOHOL
  • FEMA 2157
  • L-BORNEO CAMPHOR
  • L(-)-BORNEOL
  • L-BORNEOL
  • L-BORNYL ALCOHOL
  • L-2-HYDROXYBORNANE
  • ENDO-(1S)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-OL
  • 2-Camphanol
  • 2-HYDROXYBORNANE
  • (1S)-(-)-BORNEOL
  • [(1S)-ENDO]-(-)-BORNEOL
  • (1S)-(-)-BORNEOL FOR SYNTHESIS
  • (-)-Borneol predominantly endo, 97%
  • 2-camphanol 1,7,7-trimethyl-endo-Bicyclo[2.2.1]heptan-2-ol
  • (-) - camphor alcohol
  • (-)-Borneol solution
  • Celosia seed extract
  • (-)-(1S,4S)-Borneol
  • (1s,2r,4s)-(-)-borneo
  • 1,7,7-trimethyl-,(1S-endo)-Bicyclo[2.2.1]heptan-2-ol
  • 1-Bornyl alcohol
  • 1-bornylalcohol
  • (1S-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
  • bornel
  • BORNEOL CRYSTALS
  • (-)-BORNEOL, TERPENE STANDARD
  • (1S,2R,4S)-(-)-Borneol=(1S)-endo-(-)Borneol
  • Bicyclo2.2.1heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)-
  • 7,7-trimethyl-(1s-endo)-bicyclo(2.2.1)heptan-2-o
  • 7,7-trimethyl-(1s-endo)-bicyclo[2.2.1]heptan-2-o
  • ((1S)-END))-(-)BORNEOL
  • BORNEOL LAEVO PURE CRIST.
  • L-BORNEOL CRYSTALS 80%
  • L-BORNEOL CRYSTALS REGULAR GRADE
  • L-BORNEOL NATURAL
  • (-)-Borneol, tech. 85%
  • Bornan-2-ol
  • Camphane-6-ol
  • [1S,2R,4S,(-)]-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol
  • [1S,2R,4S,(-)]-Bornan-2-ol
  • (-)-BORNEOL WITH GC
  • (1S)-(-)-BORNEOL (-)-BORNEOL
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