ChemicalBook
Chinese english Germany Japanese Korea

(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid Produkt Beschreibung

L-carnitine Struktur
541-15-1
CAS-Nr.
541-15-1
Bezeichnung:
(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid
Englisch Name:
L-carnitine
Synonyma:
CAR-OH;ST 198;Carnitor;karnitin;USPorFCC;Carniking;Carnitene;L-CARNITIN;VITAMIN BT;Carnitrine
CBNumber:
CB4464378
Summenformel:
C7H15NO3
Molgewicht:
161.2
MOL-Datei:
541-15-1.mol

(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid Eigenschaften

Schmelzpunkt:
197-212 °C(lit.)
Siedepunkt:
287.5°C (rough estimate)
alpha 
-31 º (c=10, H2O)
Dichte
0.64 g/cm3
Brechungsindex
-32 ° (C=1, H2O)
storage temp. 
Store below +30°C.
Löslichkeit
H2O: 0.1 g/mL at 20 °C, clear, colorless
Aggregatzustand
Crystals or Crystalline Powder
pka
3.80(at 25℃)
Farbe
White
PH
6.5-8.5 (50g/l, H2O)
Wasserlöslichkeit
2500 g/L (20 ºC)
Merck 
14,1849
BRN 
4292315
Stabilität:
Hygroscopic
InChIKey
PHIQHXFUZVPYII-ZCFIWIBFSA-N
CAS Datenbank
541-15-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-37/39
WGK Germany  3
RTECS-Nr. BP2980000
3-10
Selbstentzündungstemperatur >365 °C
Hazard Note  Irritant
HS Code  29239000
Giftige Stoffe Daten 541-15-1(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: > 5000 mg/kg

(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White or almost white, crystalline powder or colourless crystals, hygroscopic.

Originator

Carnitene,Sigma Tau Industrie,Italy

Occurrence

Synthetic. It is found in its natural state in food

Verwenden

antimethemoglobinemic, cyanide antidote

Verwenden

Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations f ound in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.

Verwenden

Carniking(R) is a product for premix- and feed industry. It is particularly recommended for the enrichment of compound feed.

Verwenden

L-Carnitine is a natural, vitamin-like nutrient wich plays an important role inhuman metabolism. It is essential in the utilization of fatty acids and in transporting metabolic energy

Verwenden

Natrulon(R) RC-100 is 100% L-Carnitine. This white crystalline powder, highly hygroscopic and amino acid like material brings not only the exfoliation but also, an additional benefit of a high level of moisturization capability.

Verwenden

Natrulon(R) RC-50DG is a 50% solution of L-Carnitine in decaglycerol/water. Natrulon(R) RC-50DG to provide a truly multi-functional product: an exfoliating product with excellent moisturization capability.

Definition

ChEBI: The (R)-enantiomer of carnitine.

Manufacturing Process

9.3 g of epichlorohydrin was added at a temperature of 40°-50°C under stirring to 9.6 g of trimethylamine hydrochloride dissolved in 10 cc of water. Continuing the reaction for an hour at the above temperature, the reaction product was concentrated under reduced pressure to obtain the crystals of 3- chloro-2-oxypropyl trimethyl ammonium chloride which were recrystallized with 25 cc of ethanol. The crystals obtained by concentrating the mother liquor were also recrystallized. The yield was 17.4 g (MP 190°C, yield 91.5%). This substance occurs as white, somewhat hygroscopic crystals and is readily soluble in water or alcohol, but insoluble in benzene, toluene, ether, acetone or chloroform.
The result of analysis assuming (C6H15C10N)+Cl--calculated value: N, 7.45%; total Cl, 37.7%; Cl-, 18.88%. Observed value: N, 7.36%; total Cl, 37.54%; Cl-, 18.98%.
18.8 g of 3-chloro-2-oxypropyl trimethyl ammonium chloride was dissolved in a mixed solvent composed of 19 cc of methanol and 1 cc of water. 5.1 g of sodium cyanide dissolved in 8 cc of water was dropped into the solution at 50°C under stirring. After dropping, the mixture was held at this temperature for 30 minutes under stirring. The reaction product was then neutralized with 6 N hydrochloric acid toward pH 5, and, after cooling, sodium chloride separated out and was filtered. The filtrate was concentrated to dryness under reduced pressure, and the residue was washed with small quantity of ethanol. Drying the residue, dissolving in hot methanol, filtering off insoluble matters, and cooling mother liquor, the crystals of 3-cyano-2-axypropyl trimethyl ammonium chloride which deposited out were filtered and dried. Yield 16.7 g [MP (decomposition) 220°-223°C, yield 93.4%].
12.5 cc of concentrated hydrochloric acid was added to 17.9 g of 3-cyano-2- oxypropyl trimethyl ammonium chloride. Gradually heating the mixture on a water bath under stirring, so bringing the temperature up to 98°C at the end of about 3 hours, 9 cc of water was added. After cooling, free hydrochloric acid was neutralized with 3 cc of 6 N sodium hydroxide, and then by adding 1 g of active charcoal, the reaction product was decolorized and filtered. The filtrate was concentrated to almost dryness under reduced pressure. Then, this concentrate was, after washing with 10 cc of ethanol, dried. Yield 24.7 g.
The dried product was dissolved in 46.5 cc of glacial acetic acid by heating on a boiling water bath. The insoluble matter is removed by filtering hot, and on cooling the mother liquor, crystals of carnitine hydrochloride separated out. The crystals were filtered, washed with 10 cc of ethanol, and dried. Recrystallizing 19.7 g of the crude carnitine with methanol, 17 g of the refined carnitine was obtained [MP 195°-198°C (decomposing point), yield 86%], The overall yield of the refined carnitine through whole steps was about 74%. Carnitine thus prepared was an odorless, white, crystalline powder, having a strong acid taste.

Trademarks

Carni tor (Sigma-Tau).

Therapeutic Function

Appetite stimulant

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Levocarnitine is a naturally available compound that plays a significant role in fatty acid oxidation and energy production in the human body. It is majorly found in skeletal and cardiac muscles of mammals and facilitates the transport of long chain fatty acids into mitochondria.

Biochem/physiol Actions

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

läuterung methode

The S(L) isomer is levocarnitine, Vitamin B7. The R or S isomers crystallise from EtOH/Me2CO (hygroscopic). The R or S hydrochlorides crystallise from hot EtOH or EtOH/Et2O and have m 142o(dec). The RS-isomer crystallises from hot EtOH (hygroscopic). The RS hydrochloride crystallises in needles from hot EtOH and has m 196o(dec). [(±) Mazzetti & Lemmon J Org Chem 22 228 1957, Beilstein 4 H 513, 4 I 548, 4 II 937-8, 4 III 1632-5, 4 IV 3185.]

(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 646)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Masteam Bio-tech Co., Ltd.
86-15897918789 86-15200345168
bruce.lei@masteam.com CHINA 153 58
Wuhan Aoliqisi New Material Technology Co., Ltd.
+8613545906766
sales@whaop.com China 290 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55

541-15-1((R)-(3-Carboxy-2-hydroxypropyl)trimethylammoniumhydroxid)Verwandte Suche:


  • CARNITINE, L-
  • CARNIFEED(R)
  • CARNIKING(R)
  • CAR-OH
  • ME3-GAMMA-ABU(BETA-HYDROXY)-OH
  • (R)-BETA-HYDROXY-GAMMA-(TRIMETHYLAMMONIO)BUTYRATE
  • (R)-3-HYDROXY-4-(TRIMETHYLAMMONIO)BUTYRATE
  • L-Carnitine Tartrate,L-carnitine,Vitamin BT,L-ca greatrnitine,L-ctheirrnitine
  • 3-Hydroxy-4-(trimethylammonio)butanoate
  • Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- (8CI)
  • Carniking
  • Carniking 50
  • Carnitene
  • Carnitor
  • L-(-)-L-Carnitine
  • ST 198
  • AMMONIUM(3-CARBOXY-2-HYDROXYPROPYL)TRIMETHYL-,HYDROXIDE
  • (S)-3-Hydroxy-4-(trimethylammonio)butanoate
  • (2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Inner Salt
  • L-(3-Carboxy-2-hydroxypropyl)trimethyl Ammonium Hydroxide Inner Salt
  • Natrulon RC
  • L-Carnitine EP5th
  • L-CARNITINE extrapure
  • (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, VitaminBT
  • LEVOCARNITINE
  • L-CARNITHINE
  • L-CARNITIN
  • L(-)-CARNITINE
  • L-CARNITINE
  • L-CARNITINE BASE
  • L-CARNITINE INNER SALT
  • GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID TRIMETHYL BETAINE
  • D(+)-CARNITINE
  • D-CARNITINE
  • BETA-HYDROXY-GAMMA-TRIMETHYLAMINOBUTYRIC ACID
  • (-)-BETA-HYDROXY-GAMMA-TRIMETHYLAMINOBUTYRIC ACID INNER SALT
  • [(-)-BETA-HYDROXY-GAMMA-TRIMETHYLAMMONIO]BUTYRATE
  • B-HYDROXY-GAMMA-TRIMETHYLAMINOBUTYRIC ACID
  • BICARNESINE
  • gamma-Trimethylamino-beta-hydroxybutyrate
  • L-Carnipure(R) 50% in water
  • L-Carnipure(R) crystalline
  • trimethylbetain
  • Natrulon(R) RC-100
  • L-Carnitin blend
  • Natrulon(R) RC-50DG
  • L-3-hydroxy-4-butyrobetaine
  • CARBOXY-N,N,N-TRIMETHYL-2-PROPEN-1-AMINIUMCHLORIDE
  • CARNITINE, L-(AS)
  • LEVOCARNITINE ORAL SOLUTION
  • Levocarnitine WS
  • L-Carnitine base SynonyMs 3-hydroxy-4-(triMethylaMMonio)butanoate
  • (3-carboxy-2-hydroxypro
  • L-Carnitine, (R)-(-)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT
  • L-Carnitinete
  • VITAMIN B-GAMMA
  • VITAMIN BT
  • VITAMIN BT INNER SALT
Copyright 2019 © ChemicalBook. All rights reserved