Cholest-4-en-3-on
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- CAS-Nr.
- 601-57-0
- Bezeichnung:
- Cholest-4-en-3-on
- Englisch Name:
- 4-Cholesten-3-one
- Synonyma:
- CHOLESTENONE;4-Cholestenone;4-CHOLESTEN-3-ONE;3-Oxocholest-4-ene;3-OXO-4-CHOLESTENE;cholest-4-en-3-one;4-Cholestene-3-one;CHOLEST-4-ENE-3-ONE;3-KETO-4-CHOLESTENE;(+)-4-CHOLESTEN-3-ONE
- CBNumber:
- CB3222827
- Summenformel:
- C27H44O
- Molgewicht:
- 384.64
- MOL-Datei:
- 601-57-0.mol
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Cholest-4-en-3-on Eigenschaften
- Schmelzpunkt:
- 79-82 °C
- alpha
- 92.5 º (c=2, CHCl3)
- Siedepunkt:
- 451.27°C (rough estimate)
- Dichte
- 0.9717 (rough estimate)
- Brechungsindex
- 1.5100 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- Chloroform (Sparingly), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Optische Aktivität
- [α]23/D +91.0°, c = 2 in chloroform
- Wasserlöslichkeit
- <0.5 g/L
- BRN
- 4707774
- Stabilität:
- Stable. Incompatible with strong oxidizing agents.
- CAS Datenbank
- 601-57-0(CAS DataBase Reference)
- NIST chemische Informationen
- Cholest-4-en-3-one(601-57-0)
- EPA chemische Informationen
- Cholest-4-en-3-one (601-57-0)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
22-24/25-36-26 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
FZ7700000 |
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| TSCA |
Yes |
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| HS Code |
29142900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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Cholest-4-en-3-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells when used at a concentration of 50 μg/ml. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats when administered at doses of 700-1,000 mg/kg per day, inducing hypertrophy in and reducing the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids.
Chemische Eigenschaften
white to light yellow crystals or powder
Verwenden
4-Cholesten-3-one is used as a chiral building block for proteomics research. It is an intestinal metabolite of cholesterol and exhibits an anti-obesity effect on animals.
Allgemeine Beschreibung
Cholestenone is a cholesterol metabolite and analog, which substitutes membrane cholesterol and elevates membrane fluidity.
Cholest-4-en-3-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cholest-4-en-3-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 179)Lieferanten
601-57-0(Cholest-4-en-3-on)Verwandte Suche:
Dimethylsulfoxid
Trenbolone
6-Methylhept-5-en-2-on
Ethan
Quinocetone
3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))-
2-Cyclohexen-1-on
Dimethylsulfid
Dimethylcarbonat
Dimethylfumarat
Clethodim
Chlorthal-dimethyl
Dimethylsulfat
Dimethyl sebacate
N,N-Dimethylformamid
Androst-4-en-3,17-dion
Dimethyl ether
(2β,3β,5β,22R)-2,3,14,22,25-Pentahydroxycholest-7-en-6-on
- 17-(1,5-dimethylhexyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecah
- 17-(1,5-DIMETHYLHEXYL)-10,13-DIMETHYL-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- (+)-4-CHOLESTEN-3-ONE
- 4-CHOLESTEN-3-ONE
- 3-KETO-4-CHOLESTENE
- (+)-3-OXO-4-CHOLESTENE
- 3-OXO-4-CHOLESTENE
- CHOLEST-4-ENE-3-ONE
- CHOLESTENONE
- 3-Oxocholest-4-ene
- 4-Cholestenone
- cholest-4-en-3-one
- delta4-Cholesten-3-one
- (8S,9S,10R,13R,14S,17R)-17-((R)-1,5-DIMETHYL-HEXYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
- 10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- 4-CHOLESTEN-3-ONE, 98+%
- (8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- 3-Keto-4-cholestene, 3-Oxo-4-cholestene
- 3-Keto-4-cholestene, 3-Oxo-4-cholestene, 4-Cholesten-3-one
- delta(sup 4)-Cholestenone
- (20R)-Cholesta-4-ene-3-one
- Cholestane-4-ene-3-one
- (8S,9S,10R,13R,14S,17R)-10,13-diMethyl-17-((R)-6-Methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- (+)-4-Cholesten-3-one 98%
- 4-CHOLESTEN-3-ONE;CHOLESTENONE
- (1S,2R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
- 4-Cholestene-3-one
- (+)-4-Cholesten-3-one >
- (+)-4-Cholesten-3-one
- (+)-3-Oxo-4-Cholestene
- 601-57-0
- Complex Molecules
- Chiral Building Blocks
- Asymmetric Synthesis
- Steroids
- Steroids (Others)
- Steroids
- Steroids (Others)
- Biochemistry
