Riluzole
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- CAS-Nr.
- 1744-22-5
- Englisch Name:
- Riluzole
- Synonyma:
- RILUTEK;CBI-BB ZERO/001785;6-TRIFLUOROMETHOXYBENZOTHIAZOLE-2-YL-AMINE;6-(Trifluoromethoxy)benzo[d]thiazol-2-amine;uzoL;BF-37;NSC8463;PK 26124;RP-54274;RILUZOLE
- CBNumber:
- CB3353226
- Summenformel:
- C8H5F3N2OS
- Molgewicht:
- 234.2
- MOL-Datei:
- 1744-22-5.mol
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Riluzole Eigenschaften
- Schmelzpunkt:
- 116-118°C
- Siedepunkt:
- 296.3±50.0 °C(Predicted)
- Dichte
- 1.572±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥25 mg/mL
- Aggregatzustand
- solid
- pka
- 2.96±0.10(Predicted)
- Farbe
- white
- Merck
- 14,8223
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- FTALBRSUTCGOEG-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T,Xi |
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| R-Sätze: |
25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DL2830000 |
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| Hazard Note |
Irritant |
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| HazardClass |
6.1 |
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| PackingGroup |
II |
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| HS Code |
29342000 |
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| Toxizität |
LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizität oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Riluzole Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Rilutek was launched in Germany, the UK and US (orphan drug status) for
treatment of amyotrophic lateral sclerosis (ALS) and is the first drug approved for this
indication. A one step synthesis from 4-(trifluoromethoxy)aniline provides a supply of
the compound. The source of its neuroprotective and anticonvulsant activity is not
clearly understood. It antagonizes excitatory amino acids and blocks presynaptic
release of glutamate, is an antagonist of NMDA-induced acetylcholine release and
inhibited glutamate and quisqualate induced increases in cGMP but does not bind to
NMDA or Kainic receptors. Rilutek has no affinity for glutamate, GABAbenzodiazepine,
glycine and adenosine receptors. It easily crosses the blood brain
barrier and depresses glutamatergic neurotransmission, stabilizes voltagedependent
Na channels in their inactive form and activates G-protein dependent processes.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Labeled Riluzole, intended for use as an internal standard for the quantification of Riluzole by GC- or LC-mass spectrometry.
Biologische Aktivität
Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na + channels and inhibits GABA uptake by striatal synaptosomes.
Riluzole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Riluzole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 408)Lieferanten
1744-22-5()Verwandte Suche:
- 6-(TRIFLUOROMETHOXY)-1,3-BENZOTHIAZOL-2-AMINE
- 6-TRIFLUOROMETHOXY-BENZOTHIAZOL-2-YLAMINE
- 6-trifluoromethoxy-2-aminobenzothiazole
- 6-(TRIFLUOROMETHOXY)-2-BENZOTHIAZOLAMINE
- BUTTPARK 13\02-09
- 2-AMINO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE
- RILUZOLE
- RP-54274
- PK 26124
- [6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amine
- Amino-2 trifluoromethoxy-6 benzothiazole [French]
- BF-37
- Prestwick-03A08
- Rilutek (TN)
- Riluzol [INN-Spanish]
- Riluzole (JAN/USAN/INN)
- Riluzole [USAN:INN]
- Riluzolum [INN-Latin]
- 2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole 97%
- 2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole97%
- Riluzole(GMPofSFDA)
- 6-(Trifluoromethoxy)-2-benzothiazolamine, PK-26124, RP-54274, Rilutek
- 2-Benzothiazolamine, 6-(trifluoromethoxy)-
- Benzothiazole, 2-amino-6-trifluoromethoxy-
- 2-amino-6-trifluoromethoxy-benzothiazol
- 6-(trifluoromethoxy)-2-benzothiazolamin
- amino-2trifluoromethoxy-6benzothiazole
- 2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole
- RILUZOLE GLUTAMATE RELEASE INH
- 2-AMINO-6-(TRIFLUOROMETHOXYL)BENZOTHIAZOLE
- 2-Amino-6-(trifluoromethoxy)benzo[d)thiazole
- 6--trifluoromethoxy-2(3H)-benzothiazolone
- Riluzole, 6-(Trifluoromethoxy)-1,3-benzothiazol-2-amine
- Riluzole(Rilutek)
- Riluzole (200 mg)
- Riluzole, 98%, a glutamate antagonist
- Riluzole - CAS 1744-22-5 - Calbiochem
- white Riluzole CAS NO.1744-22-5 kf-wang(at)kf-chem.com
- 2-Amino-6-(trifluoromethoxy)benzothiazole>
- Riluzole【2-Amino-6-(trifluoromethoxy)benzothiazole】
- uzoL
- riluzole Company Standards
- Riluzole USP/EP/BP
- Riluzoler
- Riluzole (RP-54274, PK 26124)
- RiluzoleQ: What is
Riluzole Q: What is the CAS Number of
Riluzole Q: What is the storage condition of
Riluzole Q: What are the applications of
Riluzole
- Riluzole CAS:1744-22-5
- Riluzole (1604337)
- NSC8463
- NSC-8463
- NSC 8463
- CBI-BB ZERO/001785
- 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine
- 6-TRIFLUOROMETHOXYBENZOTHIAZOLE-2-YL-AMINE
- RILUTEK
- 2-Butyne,7-bromo-
- 1744-22-5
- 1744-22-4
