IDRA 21
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- CAS-Nr.
- 22503-72-6
- Englisch Name:
- IDRA 21
- Synonyma:
- AMPAKINE;IDRA 21;IDRA 21,98%;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;IDRA 21
Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
- CBNumber:
- CB3468324
- Summenformel:
- C8H9ClN2O2S
- Molgewicht:
- 232.69
- MOL-Datei:
- 22503-72-6.mol
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IDRA 21 Eigenschaften
- Schmelzpunkt:
- 209 °C(Solv: acetic acid (64-19-7))
- Siedepunkt:
- 405.1±55.0 °C(Predicted)
- Dichte
- 1.394±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 9.78±0.40(Predicted)
- Farbe
- Off-White to Pale Yellow
- InChIKey
- VZRNTCHTJRLTMU-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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IDRA 21 Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
Biologische Aktivität
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).
IDRA 21 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IDRA 21 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 142)Lieferanten
22503-72-6()Verwandte Suche:
- IDRA 21
- 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
- 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
- 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE
- IDRA 21,98%
- 7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
- 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide
- IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide
- 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...
- IDRA 21
Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
- AMPAKINE
- S-18986 IDRA-21 AMPAKINE
- 22503-72-6
- Ligand-Gated Ion Channels
- Ion Channels
- Ionotropic Glutamate Receptor Modulators
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- API
