NSC73306

79560-74-0

CAS-Nr.: 79560-74-0

Englisch Name:: NSC73306

Synonyma:: NSC73306;NSC73306 >=98% (HPLC);(3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone;Hydrazinecarbothioamide, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-N-(4-methoxyphenyl)-

CBNumber:: CB34739682

Summenformel:: C16H14N4O2S

Molgewicht:: 326.37

MOL-Datei:: 79560-74-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 4

NSC73306 Eigenschaften

Schmelzpunkt:: 240 °C(Solv: ethanol (64-17-5))

Dichte: 1.38±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

pka: 7.40±0.20(Predicted)

Aggregatzustand: powder

Farbe: yellow to light brown

Sicherheit

NSC73306 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone is a compound involved in the design and synthesis of novel anticancer agents that have the potential to overcome multidrug resistance.

Biochem/physiol Actions

NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor.

NSC73306 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NSC73306 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

NSC73306
NSC73306 >=98% (HPLC)
(3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone
Hydrazinecarbothioamide, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-N-(4-methoxyphenyl)-
79560-74-0