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Trazodon Produkt Beschreibung

Trazodone Struktur
19794-93-5
CAS-Nr.
19794-93-5
Bezeichnung:
Trazodon
Englisch Name:
Trazodone
Synonyma:
trazon;desyrel;TRAZODONE;trialodine;Trazodone-d6;Trazodone (base and/or unspecified salts);Trazodone Hydrochloride 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-tri;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,5-a]pyridin-3-one;1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
CBNumber:
CB3727463
Summenformel:
C19H22ClN5O
Molgewicht:
371.86
MOL-Datei:
19794-93-5.mol

Trazodon Eigenschaften

Schmelzpunkt:
86-870C
Dichte
1.3141 (rough estimate)
Brechungsindex
1.5790 (estimate)
pka
pKa (50% ethanol): 6.14(at 25℃)
CAS Datenbank
19794-93-5(CAS DataBase Reference)
NIST chemische Informationen
Desyrel(trazodone hcl salt)(19794-93-5)

Sicherheit

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

Trazodon Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Brown Oil

Verwenden

Antidepressant

Indications

Trazodone (Apothecon) is also classified as an antidepressant agent. It is a selective serotonin reuptake inhibitor (SSRI), partial agonist at postsynaptic 5-HT1A receptors, and exhibits α-adrenoceptor blocking actions.
Trazodone may cause priapism and enhance libido, and it prolongs nocturnal erections. This drug has been used both orally and by intracavernosal injection. It can be used alone or in combination with yohimbine. Overall, trazodone has not been as effective in treating ED as other available agents. However, it may be an option for selected patients, particularly those with performance anxiety or low libido.

Definition

ChEBI: An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Trademarks

Beneficat;Bimaran;Deprax;Devidone;Manegan;Molipaxin;Pragmarel;Pragmazone;Taxagon;Thittico;Thombran;Thromban;Tombran;Tramensan;Tritico;Trittico.

Weltgesundheitsorganisation (WHO)

Trazodone, an antidepressant indicated for the treatment of a wide range of depressive illness, was introduced in 1973. Although it is registered for use in many countries with highly evolved regulatory authorities, approval for registration was not granted in Norway because of a suspicion of carcinogenicity in a two-year rat study.

Biologische Funktion

Trazodone (Desyrel) was introduced in the early 1980s as a second-generation antidepressant. It blocks the neuronal reuptake of serotonin and is an antagonist at the 5HT2-receptor. Also, its major metabolite, mchlorophenylpiperazine (mCPP), is a postsynaptic serotonin receptor agonist. When compared to the TCAs, trazodone is relatively free of antimuscarinic side effects, but it does block the α-adrenoceptor. Common side effects include marked sedation, dizziness, orthostatic hypotension, and nausea. Priapism is an uncommon but serious side effect requiring surgical intervention in one-third of the cases reported. Because of trazodone’s sedating quality, it is often used in low doses to counter the insomnia associated with the newer antidepressants, such as the SSRIs.

Trazodon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trazodon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 67)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21751 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23967 58
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19977 64
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1791901229 1791901229@qq.com China 9078 52
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13010 57
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
Ningbo Taikang Chemical Co., Ltd. +86 (574) 8736-5517
+86 (574) 87367735 sales@taikangchem.com China 299 58

19794-93-5(Trazodon)Verwandte Suche:


  • 8-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,8,9-triazabicyclo[4.3.0]nona-2,4,9-trien-7-one
  • desyrel
  • trazon
  • TRAZODONE
  • trialodine
  • Trazodone Hydrochloride 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-tri
  • Trazodone (base and/or unspecified salts)
  • 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
  • Trazodone-d6
  • 2-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
  • 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
  • 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,5-a]pyridin-3-one
  • 19794-93-5
  • 243-317-1
  • C19H22ClN5O
  • Active Pharmaceutical Ingredients
  • Trazodone
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Serotonin receptor
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