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Gabapentin Produkt Beschreibung

Gabapentin Struktur
60142-96-3
CAS-Nr.
60142-96-3
Bezeichnung:
Gabapentin
Englisch Name:
Gabapentin
Synonyma:
ci945;go3450;goe2450;GOE-3450;NEURONTIN;AKOS 92109;GABAPENTIN;Gababentin;GABAPENTINE;gabapentino
CBNumber:
CB3263316
Summenformel:
C9H17NO2
Molgewicht:
171.24
MOL-Datei:
60142-96-3.mol

Gabapentin Eigenschaften

Schmelzpunkt:
162°C
Flammpunkt:
9℃
storage temp. 
Desiccate at +4°C
Löslichkeit
H2O: 10 mg/mL
Aggregatzustand
solid
pka
pKa1 (25°) 3.68; pKa2 10.70
Farbe
off-white
Merck 
14,4319
BRN 
2359739
CAS Datenbank
60142-96-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xi,F
R-Sätze: 61-36/37/38-39/23/24/25-23/24/25-11
S-Sätze: 53-26-36/37/39-45-36-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS-Nr. GU6496000
HazardClass  IRRITANT
HS Code  29224999
Giftige Stoffe Daten 60142-96-3(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P370+P378 Bei Brand: zum Löschen verwenden.
P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.

Gabapentin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Gabapentin was introduced in 1993 in the UK and early 1994 in the USA as an adjunctive therapy in the treatment of refractory partial seizures and secondarily generalized tonic-clonic seizures. Although being a lipophilic analog of the neurotransmitter GABA, gabapentin appears to exert its anticonvulsive function by a GABA receptor independent mechanism, possibly involving the L-system amino acid transporter protein. Gabapentin easily crosses the blood brain barrier and exhibits a favorable pharmacokinetic profile with high tolerability. It does not interfere with the metabolism of other concomitant administered antiepileptic drugs, thus having a low potential for drug interactions. Studies are currently underway for the use of gabapentin as mono-therapy for the treatment of various seizures.

Chemische Eigenschaften

White Crystalline Solid

Originator

Warner-Lambert (U.S.A.)

Verwenden

Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.

Verwenden

antipsychotic, 5HT2A antagonist

Verwenden

selective H1-receptor antagonist

Verwenden

For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).

Definition

ChEBI: A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Trademarks

Neurontin (ParkeDavis); Neurontin (Pfizer).

Biologische Funktion

Gabapentin (Neurotonin) was initially designed to be a rigid analogue of GABA. When it was discovered to have antiepileptic properties, it was assumed that this activity was related to a GABAergic mechanism. However, subsequent studies have failed to show any GABAergic activity of gabapentin. Although it has not yet been possible to ascribe any definite mechanism to its antiepileptic activity, there is recent evidence that it may function as an agonist at GABAB receptors in the brain.
Gabapentin is recommended as adjunctive therapy in the treatment of partial seizures in adults.When used with other drugs, it appears to be an effective AED; it is usually not effective when employed alone for patients with severe seizures.
Gabapentin is generally well tolerated, with somnolence, dizziness, and ataxia the most commonly reported adverse effects. A low incidence of potentially serious side effects and no significant allergic reactions have been reported.

Allgemeine Beschreibung

Gabapentin and its closely related analog pregabalin,(S)-3-isobutyl-GABA, are broad-spectrum anticonvulsantswith multiple mechanisms of action.24,51 Inaddition to modulating calcium influx and stimulateGABA biosynthesis as discussed earlier, they also competefor the biosynthesis of L-glutamic acid because oftheir structural similarity to L-leucine.51 Gabapentin andpregabalin have very little liability for causing metabolicbaseddrug–drug interactions, particularly when used incombination with other AEDs because they are not metabolizedin humans. More than 95% of the drug is excretedunchanged through the kidneys. However, there are somedifferences in their bioavailability. Unlike gabapentin,which exhibits 60% bioavailability when given in lowdoses because of intestinal uptake by a saturable smallneutral L-amino acid transporter, the absorption of pregabalinis almost complete (98%) and exhibits an ideal linear pharmacokinetic profile.24 This high bioavailability of pregabalincan be attributed to its closer structure similarity tothe essential amino acid, L-leucine.

Biologische Aktivität

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca 2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Veterinary Drugs and Treatments

Gabapentin may be useful as adjunctive therapy for refractory or complex partial seizures, or in the treatment of chronic pain in dogs or cats.

Gabapentin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Gabapentin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 340)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 488 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58

60142-96-3(Gabapentin)Verwandte Suche:


  • NEURONTIN
  • GABAPENTINE
  • GABAPENTIN HYDROCHLORIDE
  • GABAPENTIN
  • GOE-3450
  • (1-AMINOMETHYL-CYCLOHEXYL)-ACETIC ACID
  • 1-(AMINOMETHYL)CYCLOHEXANEACETIC ACID
  • AKOS 92109
  • 1-(Aminomethyl)-cyclohexaneacetic acid, Neurontin
  • Goe-3450:GOE-3450:Neurontin
  • 1-(Aminomethyl)cyclohexane-1-acetic acid
  • Gabapentin (250 mg)G0E0050.999mg/mg(ai)
  • Gabapentin (250 mg)
  • Gabapentin hydrochlo
  • Gabapentin, USP
  • Gabapentin hydrochloride API
  • Gabapentin solution
  • 1-(aminomethyl)-cyclohexaneaceticaci
  • ci945
  • gabapentino
  • go3450
  • goe2450
  • Gababentin
  • GABAPENTIN (1-(AMINOMETHYL)-CYCLOHEXANEA CETIC ACID) \ NEURONTIN
  • GABAPENTIN, USP STANDARD
  • GABAPENTIN, RELATED COMPOUND A 3,3-PENTAMETHYLENE-5-BUTYROLACTAM USP STANDARD
  • Gabapentin&IntCdaCam
  • 1-(Aminomethyl)cyclohexaneacetic Acid, Neurontin, GOE-3450
  • Cyclohexaneacetic acid, 1-(aminomethyl)-
  • GEBAPENTINE
  • GABAPENTIN,HIGHPURITY
  • 2-[1-(aminomethyl)cyclohexyl]acetic acid
  • Gabapentin, 98%, a GABA analogue
  • 60142-96-3
  • C9H17NO2HClC9H18ClNO2
  • Ligand-Gated Ion Channels
  • Ion Channels
  • GABA and Glycine Receptor Modulators
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Organic acids
  • APIs
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
  • GABA/Glycine receptor
  • Ion channels
  • API
  • ABILIFY
  • Other APIs
  • Pharmaceutical raw materials
  • Miscellaneous Biochemicals
  • -
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