Disulfoton (ISO) Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
öLIGE FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Phosphoroxidenund Schwefeloxiden.
ARBEITSPLATZGRENZWERTE
TLV: 0.05 mg/m?(als TWA); (Einatembare Fraktion) Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); BEI vorhanden; (ACGIH 2005).RET> MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Möglich sind Auswirkungen auf das Nervensystem mit nachfolgenden Krämpfenund Atemversagen. Exposition oberhalb der Arbeitsplatzgrenzwerte kann zum Tod führen. Cholinesterasehemmer. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Cholinesterasehemmer. Kumulative Wirkung möglich (s. AKUTE GEFAHREN/SYMPTOME).
LECKAGE
Belüftung. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R27/28:Sehr giftig bei Berührung mit der Haut und beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
Disulfoton is a dark yellowish oil with an aromatic, sulfurous odor. It is soluble in most
organic solvents and fatty oils. Disulfoton is a selective, systemic insecticide and acaricide.
It is used for seed coating and for soil application to protect from insect attacks, for the
control of sucking insects, aphids, leaf hoppers, thrips, beet-fl ies, spider mites, and coffeeleaf
miners. Disulfoton has been used extensively in pest control on a variety of crops,
such as cotton, tobacco, sugar beets, corn, peanuts, wheat, ornamentals, cereal grains, and
potatoes. It is grouped by the US EPA under RUP. Human exposures to disulfoton occur
through breathing contaminated air, drinking contaminated water, eating contaminated
food, and working in industries that manufacture and formulate the pesticide.
Verwenden
DISULFOTON is used as systemic insecticide and acaracide.
Definition
ChEBI: An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate.
Allgemeine Beschreibung
Disulphoton is a dark yellowish oil with an aromatic, sulphurous odour. It is soluble in most organic solvents and fatty oils. Disulphoton is a selective, systemic insecticide and acaricide. It is used for seed coating and for soil application to protect from insect attacks and for the control of sucking insects, aphids, leafhoppers, thrips, beetflies, spider mites, and coffee-leaf miners. Disulphoton has been extensively used in pest control on a variety of crops such as cotton, tobacco, sugar beets, corn, peanuts, wheat, ornamentals, cereal grains, and potatoes. It is grouped by the U.S. EPA under RUP. Human exposures to disulphoton occur through breathing contaminated air, drinking contaminated water, eating contaminated food, and working in industries that manufacture and formulate the pesticide.
Reaktivität anzeigen
Organothiophosphates, such as DISULFOTON, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
Disulfoton is highly toxic to animals and humans by all routes of exposures, namely, by
dermal absorption, through ingestion, and inhalation by the respiratory route. The symptoms
of poisoning include blurred vision, fatigue, headache, dizziness, sweating, tearing,
and salivation. It inhibits cholinesterase and affects the nervous system function. It does
not cause delayed neurotoxicity. Prolonged period of exposures to high concentrations of
disulfoton cause harmful effects to the nervous system with symptoms such as narrowing
of the pupils, vomiting, diarrhea, drooling, diffi culty in breathing, lung edema, tremors,
convulsions, coma, and death. Disulfoton causes no mutagenic or teratogenic effects in
laboratory animals. There are no reports indicating that disulfoton causes cancer in animals
or humans. The DHHS, the IARC, and the US EPA have not classifi ed disulfoton as
to its ability to cause cancer.
Brandgefahr
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Landwirtschaftliche Anwendung
Insecticide, Acaricide: All products formulated at greater than 2% disulfoton
are classified as Restricted Use Pesticides (RUP).
Disulfoton is a selective, systemic organophosphate insecticide
and acaricide that is especially effective against
sucking insects. It is used to control aphids, leafhoppers,
thrips, beet flies, spider mites, and coffee leaf miners. Not
approved for use in EU countries. There are 21 global
suppliers.
Handelsname
BAY 19639®; BAYER 19639®;
DIMAZ®; DISULFATON®; DI-SYSTON®[C];
DISYSTON®[C]; DISYSTOX®; DITHIODEMETON®;
DITHIOSYSTOX®; EKATIN TD®; FRUMIN-AL®;
FRUMIN G®; GLEBOFOS®; M-74®; S 276®;
SOLVIREX®; THIODEMETON®; THIODEMETRON®
Sicherheitsprofil
Poison by ingestion,
inhalation, skin contact, intraperitoneal, and
intravenous routes. Human mutation data
reported. When heated to decomposition it
emits veq toxic SOx and POx. See also
various demeton entries and ESTERS.
Environmental Fate
Soil/
Plant. Disulfoton was metabolized in soil and plants to the corresponding sulfoxide and sulfone via oxidation of the thioether sulfur atoms (Metcalf et al., 1957; Getzin and Shanks, 1970; Takase et al., 1972; Clapp et al., 1976; Worthing and Hance, 1991), the corresponding phosphorothioate analogs and then to derivatives of O,O-diethyl hydrogen phosphate and 2-ethylthioethyl mercaptan (Worthing and Hance, 1991). Disulfoton is rapidly oxidized in soil to its sulfoxide and sulfone with disulfoton oxon sulfoxide and disulfoton oxon sulfone appearing in small amounts (Szeto et al., 1983). In a Portneuf silt loam soil, the persistence of the sulfoxide and sulfone was 32 and >64 days, respectively (Clapp et al., 1976).
Disulfoton was translocated from a sandy loam soil into asparagus tips. Disulfoton sulfoxide, disulfoton sulfone, disulfoton oxon sulfoxide and disulfoton oxon sulfone were recovered as metabolites (Szeto and Brown, 1982; Szeto et al., 1983). Disulfoton s
Groundwater. According to the U.S. EPA (1986) disulfoton has a high potential to leach to groundwater.
Photolytic. Disulfoton was rapidly oxidized to disulfoton sulfoxide and trace amounts (<5% yield) of disulfoton sulfone when sorbed on soil and exposed to sunlight (half-life 1–4 days) (Gohre and Miller, 1986). The photosensitized oxidation was probably due to the presence of singlet oxygen (Gohre and Miller, 1986; Zepp et al., 1981). The degradation rate was higher in soils containing the lowest organic carbon (Gohre and Miller, 1986).
Chemical/Physical. Emits toxic fumes of phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987; Lewis, 1990).
When fertilizers containing superphosphate and ammonium nitrate were impregnated with disulfoton, the latter chemically degraded to form disulfoton sulfone and disulfoton sulfoxide (Ibrahim et al., 1969).
The reported half-lives for abiotic hydrolysis
Stoffwechselwegen
Disulfoton is metabolised by an analogous route to phorate. The principal
route of disulfoton metabolism in all media is activation via oxidation
of the thioether group to the sulfoxide (rapid) and sulfone (slower).
Thioether oxidation occurs preferentially to oxidative desulfuration of the
P=S group to the oxon, which is usually only present in trace amounts
and there is good evidence that the sulfoxide and sulfone oxons arise
via disulfoton sulfoxide and sulfone rather than disulfoton oxon. The
more polar thiooxidised metabolites are translocated in plants and are
responsible for the compound's systemic action.
Stoffwechsel
The metabolic
routes of disulfoton are essentially the same in plants,
insects, and mammals, involving the oxidation of the
sulfide group into the sulfoxide and then sulfone,
oxidative desulfuration to the corresponding oxons, and
hydrolysis to diethyl phosphorothioate. In mammals,
orally administered disulfoton is rapidly metabolized and
excreted in the urine. Disulfoton is rapidly degraded in
soil; DT
50 (20 ?C) was 1.3–2 d.
Disulfoton (ISO) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
