Chinese english Germany Japanese Korea

PF 573228

PF 573228 Struktur
869288-64-2
CAS-Nr.
869288-64-2
Englisch Name:
PF 573228
Synonyma:
PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;Focal Adhesion Kinase Inhibitor II;PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II;Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
CBNumber:
CB42459138
Summenformel:
C22H20F3N5O3S
Molgewicht:
491.49
MOL-Datei:
869288-64-2.mol
Request For Quotation

PF 573228 Eigenschaften

Schmelzpunkt:
>242°C (dec.)
Dichte
1.459
storage temp. 
2-8°C
Löslichkeit
DMSO: ≥20mg/mL
Aggregatzustand
powder
pka
14.30±0.20(Predicted)
Farbe
white to off-white
InChIKey
HESLKTSGTIBHJU-UHFFFAOYSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25-36
S-Sätze: 26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

PF 573228 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

Verwenden

A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

PF 573228 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF 573228 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 134)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29220 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9991 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3136 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948
 sales@aceschem.com United States 19639 58
  • PF 573228
  • 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
  • 6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one
  • 6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one
  • 2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
  • Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228
  • PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one
  • PF-228
  • PF-573228, >=98%
  • PF-573228;PF 573228
  • 3,4-DIHYDRO-6-[[4-[[[3-(METHYLSULFONYL)PHENYL]METHYL]AMINO]-5-(TRIFLUOROMETHYL)-PYRIMIDIN-2-YL]AMINO]-2(1H)-QUINOLINONE
  • 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]
  • Focal Adhesion Kinase Inhibitor II
  • CS-253
  • Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
  • 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one
  • PF 573228 USP/EP/BP
  • PF-573228 DISCONTINUED
  • PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II
  • 869288-64-2
  • C22H20F3N5O3S
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals
Copyright 2019 © ChemicalBook. All rights reserved