(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	18521735133 18521732826;	market@aladdin-e.com	China	25015	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	4494	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
Tianjin heowns Biochemical Technology Co., Ltd.	400-6387771-6038 18902104717	sales@heowns.com	China	20512	60
Jiangsu aikang biomedical research and development co., LTD	025-66110311 13155353615	qzhang@aikonchem.com	China	15527	58

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• (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
• (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
• L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
• PF04859989 hydrochloride
• PF-04859989 hydrochloride
• PF-4859989 hydrochloride
• PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
• PF-04859989 hydrochloride >=98% (HPLC)
• 2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
• (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
• PF-04859989 HCl
• PF-04859989HCl
• disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
• 177943-33-8