Terlipressin
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- CAS-Nr.
- 14636-12-5
- Bezeichnung:
- Terlipressin
- Englisch Name:
- Terlipressin acetate
- Synonyma:
- TERLIPRESSIN;Terlipressin for NMR identification;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2;Glypressin;Glycylpressin;Terilipressin;TerlipressinuM;Terlipressin CRS;Terlipressin(net);Terlipressin, >99%
- CBNumber:
- CB4266213
- Summenformel:
- C52H74N16O15S2
- Molgewicht:
- 1227.37
- MOL-Datei:
- 14636-12-5.mol
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Terlipressin Eigenschaften
- Schmelzpunkt:
- >170°C (dec.)
- Siedepunkt:
- 1824.0±65.0 °C(Predicted)
- Dichte
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 9.90±0.15(Predicted)
- Farbe
- White
- Sequenz
- Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2，(Disulfide bridge: Cys-Cys)
- InChIKey
- BENFXAYNYRLAIU-ITQMCZIINA-N
- CAS Datenbank
- 14636-12-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Terlipressin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
Chemische Eigenschaften
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (Terlipressin acetate) is White Solid
Verwenden
Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It is used norepinephrine-resistant septic shock and hepatorenal syndrome. It is also used in the treatment of acute variceal bleeding. Terlipressin Acetate 1 mg solution for injection is used for the treatment of: bleeding from dilated (widening) veins in the food pipe leading to your stomach (called bleeding oesophageal varices).
Nebenwirkungen
In clinical trials, the most common side effects of terlipressin administration were paleness, increased blood pressure, peripheral ischemia, abdominal pain, nausea, diarrhea, and headache.
Terlipressin related adverse events are common and most of terlipressin related adverse events were mild or moderate, which can be resolved spontaneously without any intervention. As terlipressin acts mainly on the splanchnic vessels, the incidence of severe ischemic complications is lower with terlipressin than with vasopressin. However, it may cause serious complications such as myocardial infarction, intestinal ischemia, peripheral cyanosis, and skin necrosis[1].
Terlipressin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Terlipressin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 394)Lieferanten
14636-12-5(Terlipressin)Verwandte Suche:
- [N-α-Triglycyl-8-lysine]-vasopressin
- 130: PN: WO2010033207 SEQID: 171 claiMed protein
- 1-Triglycyl-8-lysine Vasopressin
- Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin
- Nα-Glycyl-glycyl-glycyl-lysine-vasopressin
- Nα-Glycylglycylglycyl-vasopressin
- Nα-Gly-Gly-Gly-8-Lys-vasopressin
- Triglycyl-8-lysine-vasopressin
- TerlipressinuM
- Terlipressin acetate, >=98%
- Terlipressin Diacetate Salt
- Thymosin al Acetate
- TERLIPRESSIN ACETATE
- Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9)
- (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide
- N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
- N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-VASOPRESSIN
- H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond)
- Glypressin
- L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-N-(Gly-Gly-Gly-)-NH2
- Glycylpressin
- Gly-Gly-Gly-[Lys8]vasopressin
- Gly-Gly-Gly-L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-NH2
- Terilipressin
- Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
- Terlipressin, Terlipressine, Terlipressina, Terlipressinum
- H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH(Disulfide bond)
- Terlipressin Acetate salt
- Terlipressin, >99%
- (2S)-N-[6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-19-[[2-[[2-[(2-amino-1-oxoethyl)amino]-1-oxoethyl]amino]-1-oxoethyl]amino]-10-(3-amino
- Terlipressin CRS
- Vasopressin, N-(glycylglycylglycyl)-8-L-lysine-
- N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin USP/EP/BP
- TerlipressinuM Glycylpressin
- N-α-Triglycyl-8-lysine]-vasopressin
- Terlipressin-15N3-13C6
- TerlipressinQ: What is
Terlipressin Q: What is the CAS Number of
Terlipressin Q: What is the storage condition of
Terlipressin Q: What are the applications of
Terlipressin
- Thymosin α1 Acetate 14636-12-5
- Terlipressin(net)
- L-α-amino-n-Butyric acid
- H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
- TERLIPRESSIN
- Terlipressin for NMR identification
- 14636-12-5
- 146363-12-5
- 156-1-3
- C52H74N16O15S2
- C52H74N16O15S2C2H4O2
- hormones
- Peptide
- Amino Acid Derivatives
- 14636-12-5
