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ODM-201 Produkt Beschreibung

ODM-201 Struktur
1297538-32-9
CAS-Nr.
1297538-32-9
Englisch Name:
ODM-201
Synonyma:
0DM021;ODM-201;ODM-021;ODM 021;CS-1565;BAY-1841788;Darolutamid;Darolutamide;Darolutamide D4;ODM-201(BAY-1841788)
CBNumber:
CB43052901
Summenformel:
C19H19ClN6O2
Molgewicht:
398.85
MOL-Datei:
1297538-32-9.mol

ODM-201 Eigenschaften

Siedepunkt:
719.5±60.0 °C(Predicted)
Dichte
1.41±0.1 g/cm3(Predicted)
pka
11.10±0.10(Predicted)

Sicherheit

ODM-201 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the  testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

Beschreibung

ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

Verwenden

ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.

Einzelnachweise

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ODM-201 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 96)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com;sale@ex-biotech.com CHINA 955 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9156 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
figo.gao@foxmail.com CHINA 2833 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58

  • CS-1565
  • ODM-201(Darolutamide)
  • N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
  • 0DM021
  • BAY-1841788;ODM-021;0DM021;ODM 021
  • ODM 021
  • ODM-021
  • ODM-201
  • BAY-1841788
  • N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
  • Darolutamide
  • N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
  • Darolutamide (ODM-201)
  • ODM-201(BAY-1841788)
  • DAROLUTAMIDE;BAY-1841788
  • 1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-
  • Darolutamid
  • Darolutamide D4
  • N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)Chemicalbook-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
  • 1297538-32-9
  • C19H19ClN6O2
  • API
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