CP-944629

CP-944629 Struktur
668990-94-1
CAS-Nr.
668990-94-1
Englisch Name:
CP-944629
Synonyma:
CP-944629;CP-944629 >=98% (HPLC);1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
CBNumber:
CB44741671
Summenformel:
C19H15F3N4O
Molgewicht:
372.34
MOL-Datei:
668990-94-1.mol

CP-944629 Eigenschaften

Dichte
1.39±0.1 g/cm3(Predicted)
storage temp. 
room temp
pka
2.70±0.50(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

CP-944629 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat).

CP-944629 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CP-944629 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 7)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44941 58
Beijing Biocreative Technology Co., Ltd. 15522676233
3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 23980 58

  • CP-944629
  • 1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
  • CP-944629 >=98% (HPLC)
  • 668990-94-1
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