CP-944629

668990-94-1

CAS-Nr.: 668990-94-1

Englisch Name:: CP-944629

Synonyma:: CP-944629;CP-944629 >=98% (HPLC);1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-

CBNumber:: CB44741671

Summenformel:: C19H15F3N4O

Molgewicht:: 372.34

MOL-Datei:: 668990-94-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 7

CP-944629 Eigenschaften

Dichte: 1.39±0.1 g/cm3(Predicted)

storage temp.: room temp

pka: 2.70±0.50(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

CP-944629 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat).

CP-944629 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CP-944629 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 7)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23980	58

CP-944629
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
CP-944629 >=98% (HPLC)
668990-94-1