CP-944629
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CP-944629 속성
- 밀도
- 1.39±0.1 g/cm3(Predicted)
- 저장 조건
- room temp
- 산도 계수 (pKa)
- 2.70±0.50(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
CP-944629 C화학적 특성, 용도, 생산
Biochem/physiol Actions
CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat).CP-944629 준비 용품 및 원자재
원자재
준비 용품
CP-944629 공급 업체
글로벌( 7)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 |
3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24131 | 58 |