ETV1 Inhibitor, BRD32048 - Calbiochem

ETV1 Inhibitor, BRD32048 - Calbiochem Struktur
CAS-Nr.
Englisch Name:
ETV1 Inhibitor, BRD32048 - Calbiochem
Synonyma:
ETV1 Inhibitor, BRD32048 - Calbiochem
CBNumber:
CB44817158
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ETV1 Inhibitor, BRD32048 - Calbiochem Eigenschaften

Sicherheit

ETV1 Inhibitor, BRD32048 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable triazine compound that directly and reversibly binds to ETS family transcription factor ETV1 (KD = 17.1 μM) and reduces its transcriptional activity, independent of its binding to DNA. Selectively inhibits p300-dependent ETV1 acetylation at K33 and K116 and thereby promotes its degradation (~50 μM). Inhibits the invasion capacity of ETV1-dependent cell lines and primary melanocytes expressing NRASG12D, but not in primary melanocytes expressing NRAS. Does not affect PC3 cell line that is not dependent on ETV1 for invasion. Also it has no effect on the invasion of cancer cells expressing mutated ETV1 (K33R/K116R).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

ETV1 Inhibitor, BRD32048 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ETV1 Inhibitor, BRD32048 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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