ETV1 Inhibitor, BRD32048 - Calbiochem
- CAS No.
- Chemical Name:
- ETV1 Inhibitor, BRD32048 - Calbiochem
- Synonyms
- ETV1 Inhibitor, BRD32048 - Calbiochem
- CBNumber:
- CB44817158
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
ETV1 Inhibitor, BRD32048 - Calbiochem price More Price(1)
ETV1 Inhibitor, BRD32048 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable triazine compound that directly and reversibly binds to ETS family transcription factor ETV1 (KD = 17.1 μM) and reduces its transcriptional activity, independent of its binding to DNA. Selectively inhibits p300-dependent ETV1 acetylation at K33 and K116 and thereby promotes its degradation (~50 μM). Inhibits the invasion capacity of ETV1-dependent cell lines and primary melanocytes expressing NRASG12D, but not in primary melanocytes expressing NRAS. Does not affect PC3 cell line that is not dependent on ETV1 for invasion. Also it has no effect on the invasion of cancer cells expressing mutated ETV1 (K33R/K116R).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
ETV1 Inhibitor, BRD32048 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
ETV1 Inhibitor, BRD32048 - Calbiochem Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |