ETV1 Inhibitor, BRD32048 - Calbiochem

ETV1 Inhibitor, BRD32048 - Calbiochem 구조식 이미지
카스 번호:
상품명:
ETV1 Inhibitor, BRD32048 - Calbiochem
동의어(영문):
ETV1 Inhibitor, BRD32048 - Calbiochem
CBNumber:
CB44817158
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

ETV1 Inhibitor, BRD32048 - Calbiochem 속성

안전

ETV1 Inhibitor, BRD32048 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A cell-permeable triazine compound that directly and reversibly binds to ETS family transcription factor ETV1 (KD = 17.1 μM) and reduces its transcriptional activity, independent of its binding to DNA. Selectively inhibits p300-dependent ETV1 acetylation at K33 and K116 and thereby promotes its degradation (~50 μM). Inhibits the invasion capacity of ETV1-dependent cell lines and primary melanocytes expressing NRASG12D, but not in primary melanocytes expressing NRAS. Does not affect PC3 cell line that is not dependent on ETV1 for invasion. Also it has no effect on the invasion of cancer cells expressing mutated ETV1 (K33R/K116R).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

ETV1 Inhibitor, BRD32048 - Calbiochem 준비 용품 및 원자재

원자재

준비 용품


ETV1 Inhibitor, BRD32048 - Calbiochem 공급 업체

글로벌( 2)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

Copyright 2019 © ChemicalBook. All rights reserved