4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
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- CAS-Nr.
- 63597-44-4
- Englisch Name:
- 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- Synonyma:
- 4α-TPA;4α-pma;alpha-TPA;4ALPHA-PMA;4ALPHA-TPA;4-alpha-PMA, 4-alpha-TPA;4α-Phorbol 12-myristate 13-acetate;4a-Phorbol 12-Myristate 13-Acetate;4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
- CBNumber:
- CB4748443
- Summenformel:
- C36H56O8
- Molgewicht:
- 616.83
- MOL-Datei:
- 63597-44-4.mol
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
- Aggregatzustand
- solid
- Farbe
- white
- Sensitive
- Light Sensitive
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 26)Lieferanten
63597-44-4()Verwandte Suche:
- 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
- 4α-pma
- 4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
- (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
- 4α-TPA
- 4-alpha-Phorbol 12-Myristate 13-Acetate >99%
- 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
- 4-alpha-PMA, 4-alpha-TPA
- 4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
- 4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
- 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- 4ALPHA-PMA
- 4ALPHA-TPA
- Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
- alpha-TPA
- 4α-Phorbol 12-myristate 13-acetate
- 4a-Phorbol 12-Myristate 13-Acetate
- 63597-44-4
- Serine/Threonine Kinase Activators
- Protein Kinase C (PKC)
- Kinase/Phosphatase Biology
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- metabolite
