Phorbol-(12-myristol-13-acetyl)
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- CAS-Nr.
- 16561-29-8
- Bezeichnung:
- Phorbol-(12-myristol-13-acetyl)
- Englisch Name:
- PHORBOL 12-MYRISTATE 13-ACETATE
- Synonyma:
- TPA;12-O-TETRADECANOYLPHORBOL 13-ACETATE;Recombinant Human Tissue Plasminogen Activator;phorbol ester;factora1;,9aalpha))-;Cocarcinogen A1;Cocarcinogen C3;pma(tumorpromoter);factora1(crotonoil)
- CBNumber:
- CB2376433
- Summenformel:
- C36H56O8
- Molgewicht:
- 616.83
- MOL-Datei:
- 16561-29-8.mol
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Phorbol-(12-myristol-13-acetyl) Eigenschaften
- Schmelzpunkt:
- 65-79oC
- Siedepunkt:
- 571.87°C (rough estimate)
- Dichte
- 1.17±0.1 g/cm3 (20 ºC 760 Torr)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble
- pka
- 11.19±0.70(Predicted)
- Aggregatzustand
- Fine Crystalline Powder
- Farbe
- Off-white to light yellow
- Wasserlöslichkeit
- Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
- Sensitive
- Light Sensitive
- BRN
- 2407201
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
- InChIKey
- PHEDXBVPIONUQT-RGYGYFBISA-N
- CAS Datenbank
- 16561-29-8(CAS DataBase Reference)
- EPA chemische Informationen
- 12-O-Tetradecanoylphorbol 13-acetate (16561-29-8)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
38-36/37/38 |
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| S-Sätze: |
36/37-26 |
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| RIDADR |
2928 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
QH4377000 |
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| F |
8-10 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
II |
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| HS Code |
29153900 |
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| Giftige Stoffe Daten |
16561-29-8(Hazardous Substances Data) |
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| Toxizität |
Diesters of
phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also
known as phorbol myristate acetate, have been identified as the
potent, highly lipophilic tumor-promoting components in croton
oil. They are potent promoters of skin tumors in vivo and have
been shown to transform cultured fibroblasts and embryonic cells
previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is
shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There
appears to be a specific receptor for phorbol esters on T cells, a
finding that may account for the selective toxicity of phorbol
esters for T cells. The mechanism of tumor promotion by phorbol
esters is still largely unknown, but findings suggest an initial cell
membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events. |
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| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Verätzungen der Haut und schwere Augenschäden. |
Ätzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Phorbol-(12-myristol-13-acetyl) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R38:Reizt die Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white to off-white solid
Verwenden
4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.
Allgemeine Beschreibung
White crystals.
Air & Water Reaktionen
Practically water insoluble.
Reaktivität anzeigen
PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .
Brandgefahr
Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.
Biologische Aktivität
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
Phorbol-(12-myristol-13-acetyl) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Phorbol-(12-myristol-13-acetyl) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 239)Lieferanten
16561-29-8(Phorbol-(12-myristol-13-acetyl))Verwandte Suche:
- 13-o-acetylphorbol12-myristate
- 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
- 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
- 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
- 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
- 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
- (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
- 12-TETRADECANOYL PHORBOL 13-ACETATE
- PHORBOL 12-MYRISTATE 13-ACETATE, SYNTHET IC
- PHORBOL 12-MYRISTATE 13-ACETATE,*MOLECUL AR BIOLOGY
- PHORBOL 12-MYRISTATE 13-ACETATE FROM &
- Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa3,4benz1,2-eazulen-9-yl ester
- 4B-PHORBOL-12-MYRISTATE-13-ACETATE
- 2-ORTHO-TETRADECANOYL-PHORBOL-13-ACETATE
- O-TETRADECANOYLPHORBOL-13-ACETATE
- 12-ORTHO-TETRADECANOYLPHORBOL-13-ACETATE
- 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
- Phorbol 12-myristate 13-acetate,99%
- Phorbol 12-myristate 13-acetate,97%
- PHORBOL(12-MYRISTOYL-13-ACETYL) ANALYTICAL GRADE
- Phorbol 12-myristate 13-acetate,12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
- Phorbol 12-Myristate 13-Acetate >99.5%
- Phorbol-12-Myristate-13-acetate / 12-Tetradecanoyl phorbol-13-acetate, TPA
- PMA, TPA, Cocarcinogen A1
- 12-O-TETRADECANOYL PHORBOL-13-ACETATE;COCARCINOGEN A1; COCARCINOGEN C3
- Cocarcinogen A1
- Cocarcinogen C3
- (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
- 12-O-tetradecanoyl phorbol-13-acetate(CAS：16561-29-8)
- 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
- PHORBOL 12-MYRISTATE 13-ACETATE, SYN
- (1AR,1bS,4aR,7aS,7bS,8R,9R,9aS)
- -1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
- -9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)
- InSolution? Phorbol-12-myristate-13-acetate
- PHORBOL 12-MYRISTATE 13-ACETATE
- PHORBOL (12-MYRISTOYL-13-ACETYL)
- 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
- abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
- a-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,9a-acetate
- -e)azulen-9-ylester,(1ar-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta
- factora1
- factora1(crotonoil)
- factora1[crotonoil]
- hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1h-cyclopropa(3,4)benz(1,2
- myristicacid,9-esterwith1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydr
- myristicacid,9-esterwith1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4
- o-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-alph
- pentahydroxy-tigliadienone-monoacetate(c)monomyristate(b)
- phorbol12-tetradecanoate13-acetate
- phorbolacetate,myristate
- phorbolmonoacetatemonomyristate
- phorbolmyristateacetate
- pma(tumorpromoter)
- tetradecanoicacid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-di
- tetradecanoylphorbolacetate
- ,9aalpha))-
- 1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate
