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Solasodin Produkt Beschreibung

SOLASODINE Struktur
126-17-0
CAS-Nr.
126-17-0
Bezeichnung:
Solasodin
Englisch Name:
SOLASODINE
Synonyma:
Solasodin;Salasdine;Nsc178260;SOLASODINE;Salasodine;Sosasodine;NSC 179187;Solanidine-S;PURAPURIDINE;Solancarpine
CBNumber:
CB5132193
Summenformel:
C27H43NO2
Molgewicht:
413.64
MOL-Datei:
126-17-0.mol

Solasodin Eigenschaften

Schmelzpunkt:
200-202°
alpha 
D25 -98° (c = 0.14 in methanol); D -113° (CHCl3)
Siedepunkt:
532.75°C (rough estimate)
Dichte
1.0159 (rough estimate)
Brechungsindex
1.6400 (estimate)
storage temp. 
2-8°C
Löslichkeit
DMSO: soluble0.5mg/mL, clear (warmed)
pka
pKb 6.30(at 25℃)
Aggregatzustand
powder
Farbe
white to beige
Optische Aktivität
[α]/D -88 to -98°, c = 0.2 in methanol
InChIKey
KOZCINYDCJVLDW-GCGBSLFCSA-N
CAS Datenbank
126-17-0(CAS DataBase Reference)
NIST chemische Informationen
Solasodine(126-17-0)

Sicherheit

S-Sätze: 22-24/25
RTECS-Nr. WF1300000
Giftige Stoffe Daten 126-17-0(Hazardous Substances Data)

Solasodin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

There is still some doubt as to whether this base occurs as such in Solanum aviculare and S. xanthocarpum or whether it is an artifact formed from Sola_x0002_sonine (q.v.) during the extraction process. The base is laevorotatory having [α]20D - 92.4° (C6H6) and the following salts and derivatives have been prepared: hydrochloride, m.p. 314°C; hydriodide, m.p. 293°C; oxalate, m.p. 248°C; tartrate, m.p. 222°C; picrate, m.p. 1.4l-2°C; picrolonate, m.p. 234°C; acetyl derivative, m.p. 195°C; benzoyl compound, m.p. 2l6-7°C and the 3:5-dinitrobenzoyl derivative, m.p. 191.5-193°C. The alkaloid forms a sparingly soluble digitonide and yields Diels's hydrocarbon on selenium dehydrogenation.

Verwenden

antineoplastic, antiinflammatory

Verwenden

A potentially useful precursor.

Verwenden

Starting material for steroidal drugs.

Sicherheitsprofil

Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

Solasodine crystallises (as monohydrate) from MeOH as lustrous plates (on heating, the plates change to needles as they melt and resolidify in needles), or aqueous 80% EtOH, and sublimes at high vacuum. After recrystallisation from H2O, m 198-199o, then from Me2CO/H2O, m 199-201o, it has [] D 22 -109.3o (c 0.581, CHCl3). On TLC with silica gel G (*C6H6/absolute EtOH, 8:2) it has RF 0.45. IR (KBr): max at 10.3, 10.4, 11.2, 11.5 (azaoxaspirane bands). [Schreiber & Rnsch Tetrahedron 20 1939 1964, Uhle J Org Chem 27 656 1962, Kessar et al. Tetrahedron 27 2153 1971, Beilstein 27 III/IV 2000.]

Einzelnachweise

Rochelmeyer, Chen., Arch. Pharm., 277,329 (1939)
Briggs., J. Chem. Soc., 3, (1942)
Briggs et al., ibid, 3013 (1950)
Absolute configuration: Boll, Phillipsborn., Acta Chem. Scand., 19, 1365 (1965)
Synthesis: Schreiber, Walther, Ronsch., Tetrahedron, 20, 1939 (1964)
Adam, Schreiber., Experientia, 21,471 (1965)
Adam, Schreiber., Tetrahedron, 22,3591 (1966)

Solasodin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Solasodin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 173)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58

126-17-0(Solasodin)Verwandte Suche:


  • (3beta,22alpha,25r)-spirosol-5-en-3-o
  • Solanum nigrum L.
  • SOLANCARPIDINE
  • SOLASOD-5-EN-3BETA-OL
  • SOLASODINE
  • PURAPURIDINE
  • delta5-20betaf,22alphaf,25alphaf,27-azaspirosten-3beta-ol
  • Salasdine
  • Salasodine
  • Solanidine-S
  • Solasodin
  • Solasodine hydrochloride base
  • Sosasodine
  • Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-piperidine], spirosol-5-en-3-ol deriv.
  • Spirosol-5-en-3-ol
  • Spirosol-5-en-3-ol, (3beta,22alpha,25R)-
  • 5-SOLASODEN-3BETA-OL
  • Solasod-5-en-3β-ol
  • Salasod-5-en-3β-ol
  • Nsc178260
  • Solancarpine
  • (3β,22α,25R)-Spirosol-5-en-3-ol
  • NSC 179187
  • Solasod-5-en-3β-ol (7CI,8CI)
  • Spirosol-5-en-3-ol, (3β,22α,25R)-
  • (4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol
  • 126-17-0
  • C27H43NO2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
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