LACTACYSTIN

LACTACYSTIN Struktur
133343-34-7
CAS-Nr.
133343-34-7
Englisch Name:
LACTACYSTIN
Synonyma:
Lacta;Aids008388;LACTACYSTIN;Aids-008388;(+)-LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN USP/EP/BP;LACTACYSTIN, SYNTHETIC;LACTACYSTIN, STREPTOMYCES SP;S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
CBNumber:
CB5136696
Summenformel:
C15H24N2O7S
Molgewicht:
376.43
MOL-Datei:
133343-34-7.mol

LACTACYSTIN Eigenschaften

Schmelzpunkt:
233-235°C dec.
Siedepunkt:
714.9±60.0 °C(Predicted)
Dichte
1.367±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
Aggregatzustand
powder
pka
3.11±0.10(Predicted)
Farbe
White to off-white
Wasserlöslichkeit
Soluble to 10 mM in water
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.

Sicherheit

WGK Germany  3

LACTACYSTIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.

Chemische Eigenschaften

White Powder

Verwenden

Lactacystin has been used:
  • as a proteasome inhibitor to inhibit protein degradation
  • to inhibit proteasomal activity of cells for live cell imaging
  • to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
  • to provide unilateral injection to animals to induce nigrostriatal lesions

Definition

ChEBI: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.

Allgemeine Beschreibung

Lactacystin is an antibiotic?and a metabolite of Streptomyces?spp.

LACTACYSTIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


LACTACYSTIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 114)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953
info@konochemical.com China 2995 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8475 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33349 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32344 50

133343-34-7()Verwandte Suche:


  • (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER
  • 3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE
  • (+)-LACTACYSTIN
  • LACTACYSTIN
  • LACTACYSTIN (NATIVE)
  • LACTACYSTIN, STREPTOMYCES SP
  • LACTACYSTIN, SYNTHETIC
  • N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE
  • (2R)-2-(Acetylamino)-3-[[(2R)-3β-hydroxy-4β-methyl-2-[(S)-1-hydroxy-2-methylpropyl]-5-oxopyrrolidine-2-yl]carbonylthio]propanoic acid
  • (2R)-2-(Acetylamino)-3-[[[(2R,3S,4R)-2-[(1S)-2-methyl-1-hydroxypropyl]-3-hydroxy-4-methyl-5-oxopyrrolidin-2-yl]carbonyl]thio]propionic acid
  • S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
  • Aids008388
  • Aids-008388
  • L-Cysteine, N-acetyl-, (2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester)
  • N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-Methylpropyl]-4-Methyl-5-oxo-D-prolyl]-L-cysteine
  • Lacta
  • LACTACYSTIN USP/EP/BP
  • L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-
  • 133343-34-7
  • C15H24N2O7S
  • Biochemicals and Reagents
  • BioChemical
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Proteasome inhibitor
  • P to Q
  • All Inhibitors
  • Inhibitors
  • Metabolites
  • Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
  • InhibitorsProtease Inhibitors
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • P to
  • Protease Inhibitor Specificity Index
  • Proteasome inhibitor
  • Proteasome inhibitorEnzyme Inhibitors by Enzyme
  • Proteasomes
  • Protease
  • ProteaseInhibitors
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