락타시스틴
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락타시스틴 속성
- 녹는점
- 233-235°C dec.
- 끓는 점
- 714.9±60.0 °C(Predicted)
- 밀도
- 1.367±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO(최대 20mg/ml), 물(최대 10mg/ml) 또는 에탄올(최대 1mg/ml)에 용해됩니다.
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 3.11±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- Soluble to 10 mM in water
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 1개월 동안 보관할 수 있습니다. 물에 용해된 용액은 안정적이지 않으므로 영업일 기준으로 하루 안에 사용해야 합니다. 수용액은 보관하면 안 됩니다.
안전
WGK 독일 | 3 |
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락타시스틴 C화학적 특성, 용도, 생산
개요
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.화학적 성질
White Powder용도
Lactacystin has been used:- as a proteasome inhibitor to inhibit protein degradation
- to inhibit proteasomal activity of cells for live cell imaging
- to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
- to provide unilateral injection to animals to induce nigrostriatal lesions
정의
ChEBI: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.일반 설명
Lactacystin is an antibiotic?and a metabolite of Streptomyces?spp.락타시스틴 준비 용품 및 원자재
원자재
준비 용품
락타시스틴 공급 업체
글로벌( 123)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29822 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 23999 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 |
cooperation@kean-chem.com | China | 40068 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
락타시스틴 관련 검색:
L-시스테인
CLASTO-LACTACYSTIN,Clasto-lactacystin -Lactone, Omuralide,Clasto-lactacystin b-Lactone, Omuralide,CLASTO-LACTACYSTIN B-LACTONE
MG-132
(+)-LACTACYSTIN ALLYL ESTER,LACTACYSTIN ALLYL ESTER
MG-115
N-PROPYL 3-MERCAPTOPROPIONATE
3,3'-THIODIPROPANOL
S-Butyl-D-cysteine
dacisteine
(S)-4-Hydroxy-2-pyrrolidinone
Fudosteine
S-Methyl 2-methylthiobutyrate
LACTACYSTIN
N-ACETYL-S-(3-HYDROXYPROPYL)CYSTEINE
5,5-Dimethyl-2-pyrrolidinone
clasto-lactacystin β-lactone,LACTACYSTIN, CLASTO-, BETA-LACTONE,CLASTO-LACTACYSTIN BETA-LACTONE
S-METHYL 4-METHYLPENTANETHIOATE
5-HYDROXYMETHYL-3-METHYLPYRROLIDIN-2-ONE