Thiamet G Discontinued
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- CAS-Nr.
- 1009816-48-1
- Englisch Name:
- Thiamet G Discontinued
- Synonyma:
- CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- CBNumber:
- CB52485666
- Summenformel:
- C9H16N2O4S
- Molgewicht:
- 248.3
- MOL-Datei:
- 1009816-48-1.mol
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Thiamet G Discontinued Eigenschaften
- Siedepunkt:
- 483.2±55.0 °C(Predicted)
- Dichte
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- H2O: ≥5mg/mL at warmed to 60°C
- Aggregatzustand
- powder
- pka
- 13.17±0.70(Predicted)
- Farbe
- white to beige
- Optische Aktivität
- [α]/D -21 to -26°, c = 0.3 in methanol
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- PPAIMZHKIXDJRN-UKPHHSARSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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Thiamet G Discontinued Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological
Biochem/physiol Actions
Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.
Thiamet G Discontinued Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Thiamet G Discontinued Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 116)Lieferanten
- Thiamet G Discontinued
- Thiamet G
- 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline
- 2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio
- 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
- (3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
- (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- Thiamet G0nDiscontinued
- CS-1700
- (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
- Thiamet G_x000b_Discontinued
- Thiamet H
- 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
- 1009816-48-1
- Carbohydrates & Derivatives
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- API
- Intermediates
