Fosamprenavir calcium
|
|
|
- CAS-Nr.
- 226700-81-8
- Englisch Name:
- Fosamprenavir calcium
- Synonyma:
- Telzir;Lexiva;GW-433908G;FOSAMPRENAVIR;GW-433908;GW-433908G;fosamprenavir calcium;FOSAMPRENAVIR, CALCIUM SALT;Fosamprenavir Calcium (200 mg);Fosamprenavir Calcium (GW433908G);Fosamprenavir & Fosamprenavir Calcium
- CBNumber:
- CB5496914
- Summenformel:
- C25H34CaN3O9PS
- Molgewicht:
- 623.668921
- MOL-Datei:
- 226700-81-8.mol
|
Fosamprenavir calcium Eigenschaften
- Schmelzpunkt:
- 282-2840C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Aqueous Acid (Slightly), DMF (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- BCS Class
- 2
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
|
P201, P202, P281, P308+P313, P405,P501 |
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
Fosamprenavir calcium Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fosamprenavir, a prodrug of the HIV protease inhibitor amprenavir, is indicated for the
oral treatment of HIV infection in adults in combination with other antiretroviral agents.
Although amprenavir has excellent antiviral potency and good tolerability, its watersolubility
is poor (0.04 mg/ml). As a result, the formulation of the agent includes a high
percentage of organic excipients to facilitate gastric dissolution, which limits the amount
of active drug that can be formulated per capsule. Fosamprenavir is a highly soluble
phosphate ester of amprenavir. It allows more convenient dosing and reduction in pill
counts as compared to amprenavir. Fosamprenavir is readily prepared in two steps
starting from a key intermediate used in the synthesis of amprenavir, by phosphorylating
a hydroxyl group and subsequently reducing a p-nitrophenyl to a p-aminophenyl group.
Fosamprenavir has little or no antiviral activity in vitro. After oral administration, it is
rapidly and almost completely hydrolyzed by phosphatases in the gut epithelium to
amprenavir prior to reaching systemic circulation. The time to reach peak plasma
concentration of amprenavir is approximately 2.5 h and the plasma elimination half-life
is approximately 7.7 h. Amprenavir is metabolized in the liver by CYP3A4 and ＞90% of
the dose is excreted as metabolites in urine and feces. In most patients, fosamprenavir is
administered at daily doses of 700–1400 mg in conjunction with ritonavir. Monotherapy
with fosamprenavir is only recommended in antiretroviral therapy-na?ve patients and the
dosing regimen is 1400 mg twice daily. The most common adverse events experienced
with fosamprenavir are diarrhea, nausea, vomiting, headache and rash.
Chemische Eigenschaften
White Microcrystalline Needles
Allgemeine Beschreibung
Fosamprenavir is used in combination with otherHIV drugs in adult patients. Like the other PIs, this compoundis a prodrug that produces the active drug uponhydrolysis. In this case, the active drug is amprenavir, apeptidomimetic transition state inhibitor. Fosamprenaviris typically administered in combination with RTinhibitors.
Clinical Use
Fosamprenavir calcium has been approved for the treatment of HIV in adults when used in combination
with other anti-HIV drugs. It is a prodrug that, on hydrolysis by serum phosphatases, gives rise to
amprenavir, which is a peptidomimetic transition-state inhibitor that targets HIV-1 protease and reduces
the viral replication and, thus, the infectiousness of HIV-1. It is commonly administered in combination
with RT inhibitors to produce excellent efficacy in patients with AIDS. The drug is administered as two
700 mg tablets twice daily or, in combination with ritonavir, can be given as two 700 mg tables once daily
or one 700 mg tablet twice daily. As a result, formaprenavir lowers the "pill burden" in patients with AIDS.
Fosamprenavir calcium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fosamprenavir calcium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 126)Lieferanten
226700-81-8()Verwandte Suche:
- FOSAMPRENAVIR, CALCIUM SALT
- calcium [(3s)-oxolan-3-yl] n-[(2s,3r)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate
- fosamprenavir calcium
- FOSAMPRENAVIR
- GW-433908G
- Lexiva
- Telzir
- [(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenyl-butan-2-yl]oxyphosphonic acid
- Fosamprenavir & Fosamprenavir Calcium
- GW-433908;GW-433908G
- FOSAMPRENAVIR CALCIUM SALT (GW433908G)
- (Calcium(2R,3S)-1-{[(4-aminophenyl)sulfonyl](2-
methylpropyl) amino}-4phenyl-3-({[(3S)-tetrahydrofuran3-yloxy]carbonyl} amino)butan-2-yl phosphate)
- Fosamprenavir Calcium (GW433908G)
- Calcium (2R,3S)-1-(4-amino-N-isobutylphenylsulfonamido)-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butan-2-yl phosphate
- Fosamprenavir Calcium SaltQ: What is
Fosamprenavir Calcium Salt Q: What is the CAS Number of
Fosamprenavir Calcium Salt Q: What is the storage condition of
Fosamprenavir Calcium Salt Q: What are the applications of
Fosamprenavir Calcium Salt
- Fosamprenavir Calcium (200 mg)
- 226700-81-8
- C25H36N3O9PS
- C25H34CaN3O9PS
- C25H36N3O9PSCa
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Fosamprenavir
- peptides
