3-Iodo-L-tyrosin
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- CAS-Nr.
- 70-78-0
- Bezeichnung:
- 3-Iodo-L-tyrosin
- Englisch Name:
- 3-IODO-L-TYROSINE
- Synonyma:
- H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH
- CBNumber:
- CB5721061
- Summenformel:
- C9H10INO3
- Molgewicht:
- 307.09
- MOL-Datei:
- 70-78-0.mol
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3-Iodo-L-tyrosin Eigenschaften
- Schmelzpunkt:
- 210 °C (dec.)(lit.)
- Dichte
- 1.7280 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- dilute aqueous acid: soluble
- Aggregatzustand
- Solid
- Siedepunkt:
- 391.0±42.0 °C(Predicted)
- pka
- 2.21±0.20(Predicted)
- Farbe
- White to off-white
- Sensitive
- Light Sensitive
- Merck
- 14,5047
- BRN
- 2941266
- Stabilität:
- Hygroscopic
- InChIKey
- UQTZMGFTRHFAAM-ZETCQYMHSA-N
- CAS Datenbank
- 70-78-0(CAS DataBase Reference)
- EPA chemische Informationen
- L-Tyrosine, 3-iodo- (70-78-0)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Verätzungen der Haut und schwere Augenschäden. |
Ätzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
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3-Iodo-L-tyrosin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Solid
Verwenden
3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.
Definition
ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.
Allgemeine Beschreibung
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).
läuterung methode
Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]
3-Iodo-L-tyrosin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Iodo-L-tyrosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 236)Lieferanten
70-78-0(3-Iodo-L-tyrosin)Verwandte Suche:
O-(4-Hydroxy-3-iodphenyl)-3-iod-L-tyrosin
Tiratricol
4-(4-Hydroxy-3,5-diiodphenoxy)-3,5-diiodphenylessigsure
3,5-Diiodthyronin
Liothyronin
Levothyroxinnatrium
N-Acetyl-3,5-diiod-L-tyrosin
3,6-Dimethylpiperazin-2,5-dion
3,5-Diiodtyrosin
D-4-(4-Hydroxy-3,5-diiodphenoxy)-3,5-diiodbenzylalanin
3-Iodo-L-tyrosin
3,5-Diiod-L-tyrosin
DL-Thyroxin
N-(N-Acetyl-3-phenyl-L-alanyl)-3,5-diiodo-L-tyrosin
Liothyroninnatrium
- 3-Iodo-4-hydroxyphenylalanine
- 4-Hydroxy-3-iodophenylalanine
- (S)-2-AMino-3-(4-hydroxy-3-iodophenyl)propanoic acid
- L-TYROSINE, 3-IODO-
- 3-I-L-Tyr-OH
- 3-Iodo-L-tyrosine≥ 98% (HPLC)
- H-L-Phe(3-I,4-OH)-OH
- 3-IODO-TYROSINE
- 3-IODO-L-TYROSINE
- 3-MONOIODO-L-TYROSINE
- S(-)-3-IODO-4-HYDROXY-PHENYLAMINE
- M-IODO-L-TYROSINE
- 3-iodine-L- tyrosine
- H-TYR(M-I)-OH
- H-TYR(3-I)-OH
- H-L-TYR(3-I)-OH
- H-3-IODO-TYR-OH
- H-3-I-PHE(4-OH)-OH
- H-3-I-TYR-OH
- 3-Monoiodo-L-tyrosine 3-Iodo-L-tyrosine
- Iodotyrosine
- (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
- 3-IODO-L -TYROSINE 97%
- 3-Iodo-L-tyrosine,97%
- 3-Iodo-Tyr-OH
- 3-Iodo-L-tyrosine,3-Monoiodo-L-tyrosine
- 3-Iodo-L-tyrosine, 97% 1GR
- (2S)-2-ammonio-3-(4-hydroxy-3-iodophenyl)propanoate
- 3-Iodo-L-tyrosine>
- 3-1odo-L-tyrosine
- 3-IODO-L-TYROSINE USP/EP/BP
- Liothyronine Impurity 1
- MIT (amino acid)
- NSC210787
- Tyrosine,3-iodo-, L- (8CI)
- Liothyronine Impurity 2
- Metoprolol Impurity 35
- H-Tyr
- 70-78-0
- IC6H34OHCH2CHNH2CO2H
- C9H10INO3
- Tyrosine Derivatives
- Unnatural Amino Acid Derivatives
- Peptide Synthesis
- Specialty Synthesis
- amino
- Unusual Amino Acids
- Amino Acids 13C, 2H, 15N
- Amino Acids
- Biochemistry
- Biological-modified Amino Acids
- Amino Acids & Derivatives
- Inhibitors
- Aromatics
- Chiral Reagents
