Fasudil hydrochloride
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- CAS-Nr.
- 105628-07-7
- Englisch Name:
- Fasudil hydrochloride
- Synonyma:
- CS-520;HA-1077;FASUDEL;CS-1572;Fasudil-HA;FASUDIL HCL;HA-1077 HCl;FASUDIL, MONOHCL;Fasudil (HA-1077);Fasudil HCl, >=99%
- CBNumber:
- CB6101699
- Summenformel:
- C14H18ClN3O2S
- Molgewicht:
- 327.83
- MOL-Datei:
- 105628-07-7.mol
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Fasudil hydrochloride Eigenschaften
- Schmelzpunkt:
- 220.5°; mp 219.3° (Shirotani)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- H2O: >200 mg/mL
- Aggregatzustand
- solid
- Farbe
- white
- Wasserlöslichkeit
- Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
- Merck
- 14,3942
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
- InChIKey
- LFVPBERIVUNMGV-UHFFFAOYSA-N
- SMILES
- N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl
- CAS Datenbank
- 105628-07-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
22 |
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| S-Sätze: |
36-60 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
HM4031166 |
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| HS Code |
29339900 |
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| Toxizität |
LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Fasudil hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed
for the treatment of cerebral vasospasm following subarachnoid hemorrhage
(SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase
C. In contrast to other calcium channel blockers, which regulate the influx of calcium
ions through the cell membrane but not involved in the intracellular regulatory
mechanism of the calcium, fasudil was suggested to have an intracellular mode of
action in relaxing vascular smooth muscle. In patients with neurological deficits due to
vasospasm, fasudil decreased the occurrence of angiographic severe and
symptomatic vasospasm and cerebral infarction without decreasing systemic blood
pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of
cerebral vascular diseases and angina pectoris.
Verwenden
vasodilator, potent Rho-kinase inhibitor
Fasudil hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fasudil hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 451)Lieferanten
105628-07-7()Verwandte Suche:
- 1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
- Fasudil Monohydrochloride
- (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL
- 5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE
- HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE
- HA-1077
- HA-1077 DIHYDROCHLORIDE
- FASUDEL
- FASUDIL DIHYDROCHLORIDE
- FASUDIL HCL
- FASUDIL HYDROCHLORIDE
- Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
- Fasudil Monohydrochloride Salt >99%
- Hydrochloride Fasudil
- Fasudil (HA-1077)
- Fasudil HCl (HA-1077)
- Fasudil (HA-1077) HCl
- 1-(Isoquinolin-5-ylsulfonyl)perhydro-1,4-diazepine hydrochloride
- Fasudil HCl, >=99%
- Fasudil (HA-1077) hydrochloride
- Isoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
- FASUDIL, MONOHCL
- 1-(5-ISOQUINOLINYLSULFONYL)HOMOPIPERAZINE DIHYDROCHLORIDE
- 1-(5-ISOQUINOLINESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, DIHYDROCHLORIDE
- 1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE 2HCL
- 1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE DIHYDROCHLORIDE
- 1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE HCL
- 5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride
- HA-1077 HCl
- CS-520
- CS-1572
- HA-1077; AT-877; FASUDIL ; FASUDIL HCL
- Fasudil-HA
- 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
- FasudilHydrochloride>
- 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride
- Fasudil hydrochloride USP/EP/BP
- Fasudil HydrochlorideQ: What is
Fasudil Hydrochloride Q: What is the CAS Number of
Fasudil Hydrochloride Q: What is the storage condition of
Fasudil Hydrochloride
- Hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride
- D-Tryptophan methyl ester hydrochloride 14907-27-8
- Fasudil hydrochloride hcl
- HOMOPIPERAZINE HYDROCHLORIDE
- 105628-07-7
- 106528-07-7
- C14H17N3O2SHCl
- C14H17N3O2SClH
- BioChemical
- Calcium Channel Modulators
- Cell Signaling and Neuroscience
- Cell Biology
- Voltage-gated Ion Channels
- Inhibitors and Activators
- Ion Channels
- Cardiovascular & Blood System Agents
- Inhibitors
- Inhibitor
- API
- APIs
