Ganirelix
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- CAS-Nr.
- 129311-55-3
- Englisch Name:
- Ganirelix
- Synonyma:
- Ganirelix USP/EP/BP;Ganirelix acetate salt;183552-38-7 (free base);Ganirelix Diacetate salt;GANIRELIX (ACETATE);183552-38-7 (FREE BASE);N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylaMino)Methylene]-D-lysyl-L-leucyl-N6-[bis(ethylaMino)Methylene]-L-lysyl-L-prolyl-;N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate
- CBNumber:
- CB62130570
- Summenformel:
- C80H113ClN18O13
- Molgewicht:
- 1570.31902
- MOL-Datei:
- 129311-55-3.mol
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Ganirelix Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
- pka
- 4.2 (3-pyridinylalanine); 9.8 (tyrosine)
- Aggregatzustand
- lyophilized powder
- Farbe
- white
- InChIKey
- GJNXBNATEDXMAK-PFLSVRRQSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Ganirelix Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ganirelix acetate was introduced in Germany as prefilled syringes for subcutaneous
injections that inhibit premature luteinizing hormone surges in women undergoing
controlled ovarian hyperstimulation. This decapeptide analog of luteinizing hormonereleasing
hormone (LH-RH) is the second third-generation LH-RH antagonist to be
launched after citrorelix (Asta Medica). This highly bioavailable compound immediately
blocks the endogenous release by the pituitary gland of luteinizing hormone (LH) and
follicle-stimulating hormone (FSH), the hormone that induces ovulation. After
discontinuation of the treatment, the pituitary-gonadal function is rapidly recovered due to
its short-half life. As a consequence, ganirelix at daily doses of 0.25 mg S.C. efficiently
prevented LH surges during clinical trials in infertile women under controlled ovarian
hyperstimulation with recombinant FSH before in vitro fertilization or similar reproductive
techniques. Unlike first and second-generation gonadotropin-releasing hormone
antagonists, ganirelix has minimal histamine-releasing effects thus avoiding the formation of edema of the face and extremities. Ganirelix is very resistant to hydrolysis and, in contrast to the already established cetrorelix, has good water solubility.
Verwenden
Decapeptide LH-RH antagonist. Used in treatment of infertility.
Ganirelix Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ganirelix Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 67)Lieferanten
129311-55-3()Verwandte Suche:
- N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylaMino)Methylene]-D-lysyl-L-leucyl-N6-[bis(ethylaMino)Methylene]-L-lysyl-L-prolyl-
- Ganirelix acetate salt
- N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate
- 183552-38-7 (free base)
- GANIRELIX (ACETATE);183552-38-7 (FREE BASE)
- Ganirelix USP/EP/BP
- Ganirelix Diacetate salt
- 129311-55-3
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
