5-Ethynyl-2'-deoxycytidine

69075-47-4

CAS-Nr.: 69075-47-4

Englisch Name:: 5-Ethynyl-2'-deoxycytidine

Synonyma:: 5-Ethynyl-2'-dC;-Ethynyl-2’5-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine;2'-Deoxy-5-ethynylcytidine;5-Ethynyl-2'-deoxycytidine>Cytidine, 2'-deoxy-5-ethynyl-;5-Ethynyl-2′-deoxycytidine, (EdC);5-Ethynyl-2'-deoxycytidine 69075-47-4;5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR

CBNumber:: CB62682226

Summenformel:: C11H13N3O4

Molgewicht:: 251.24

MOL-Datei:: 69075-47-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 53

5-Ethynyl-2'-deoxycytidine Eigenschaften

Schmelzpunkt:: 191 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1))

Siedepunkt:: 475.7±55.0 °C(Predicted)

Dichte: 1.54±0.1 g/cm3(Predicted)

storage temp.: Store at 2-8°C, protect from light, stored under nitrogen

Löslichkeit: DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

pka: 14.03±0.60(Predicted)

Aggregatzustand: powder to crystal

Farbe: White to Light yellow to Light orange

maximale Wellenlänge (λmax): 292nm(H2O)(lit.)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

WGK Germany	3
HS Code	2934.99.4400

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

5-Ethynyl-2'-deoxycytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

5''-Ethynyl-2''-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID₅₀ = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1'',2''-³H]deoxyuridine over [CH₃-³H]deoxythymidine in PRK cells (ID₅₀s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID₅₀s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.

Verwenden

5-Ethynyl-2’-deoxycytidine is an lower toxicity analog of 2’-deoxycytidine, a metabolic labeling probe for DNA synthesis. 5-Ethynyl-2’-deoxycytidine is most commonly used when thymidine analogs is undesirable.

5-Ethynyl-2'-deoxycytidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-Ethynyl-2'-deoxycytidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 53)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10026	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9425	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

5-Ethynyl-2′-deoxycytidine, (EdC)
Cytidine, 2'-deoxy-5-ethynyl-
2'-Deoxy-5-ethynylcytidine
5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR
5-Ethynyl-2'-deoxycytidine
5-Ethynyl-2'-dC
4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
-Ethynyl-2&rsquo
5-Ethynyl-2'-deoxycytidine>
5-Ethynyl-2'-deoxycytidine 69075-47-4
5-Ethynyl-2'-deoxycytidine
69075-47-4
Carbohydrates & Derivatives, Heterocycles, Nucleotides, Bases & Related Reagents