4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid
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- CAS-Nr.
- 19135-17-2
- Bezeichnung:
- 4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid
- Englisch Name:
- NPGB
- Synonyma:
- NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
- CBNumber:
- CB6287205
- Summenformel:
- C14H13ClN4O4
- Molgewicht:
- 336.73
- MOL-Datei:
- 19135-17-2.mol
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4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Eigenschaften
- Schmelzpunkt:
- 241-243 °C
- storage temp.
- -20°C
- BRN
- 8024554
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36 |
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| S-Sätze: |
26 |
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| WGK Germany |
3 |
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| F |
8-10 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augenschäden. |
Schwere Augenschädigung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
Allgemeine Beschreibung
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
Biochem/physiol Actions
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
Einzelnachweise
[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:
10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:
10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:
10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:
10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:
10.1021/jm00154a015.
4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 14)Lieferanten
19135-17-2(4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid)Verwandte Suche:
- 4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
- 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
- NPGB
- PNPGB
- P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE
- P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE
- P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE
- Nsc163801
- 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride
- P-NITROPHENYL P'-GUANIDINOBENZOATE HCL
- 4-NITROPHENYL 4-GUANIDINOBENZOATE &
- p-nitrophenyl-p'-guanidinobenzoateHClcrystalline
- p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline
- Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride
- 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
- (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride
- 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate
- 19135-17-2
- C14H12N4O4HCl
- Substrates by Enzyme
- Chromogenic
- Enzymes, Inhibitors, and Substrates
- Enzyme Substrates
- Activity
- BioChemical
- Biochemicals and Reagents
