AZD2098

566203-88-1

CAS-Nr.: 566203-88-1

Englisch Name:: AZD2098

Synonyma:: AZD2098;AZD 2098 NEW;AZD-2098 >=98% (HPLC);AZD 2098;AZD-2098;AZD2098;2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide;Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-;AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098

CBNumber:: CB63175527

Summenformel:: C11H9Cl2N3O3S

Molgewicht:: 334.18

MOL-Datei:: 566203-88-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 52

AZD2098 Eigenschaften

Schmelzpunkt:: 185-186°C

Siedepunkt:: 489.3±55.0 °C(Predicted)

Dichte: 1.569±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: Soluble in DMSO (>25 mg/ml)

pka: 5.56±0.40(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Stabilität:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

AZD2098 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ～120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

AZD2098 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AZD2098 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 52)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4647	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

AZD2098
AZD 2098 NEW
AZD 2098;AZD-2098;AZD2098
2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-
AZD-2098 >=98% (HPLC)
AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098
566203-88-1
C11H9Cl2N3O3S