InSolution PARP Inhibitor VIII, PJ34 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC
50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC
50 = 200 μM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 μM to 10 μM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC
50 = 20 nM). Exhibits neuroprotective effects in
in vivo and
in vitro models of stroke. The solid form of this compound (Cat. No.
528150) is also available.
Biochem/physiol Actions
Cell permeable: yes
InSolution PARP Inhibitor VIII, PJ34 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
