A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 μM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 μM to 10 μM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150) is also available.
Biochem/physiol Actions
Cell permeable: yes
InSolution PARP Inhibitor VIII, PJ34 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
InSolution PARP Inhibitor VIII, PJ34 - Calbiochem 공급 업체