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(R)-CPP

(R)-CPP Struktur
126453-07-4
CAS-Nr.
126453-07-4
Englisch Name:
(R)-CPP
Synonyma:
D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid;(R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid;[3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
CBNumber:
CB6725314
Summenformel:
C8H17N2O5P
Molgewicht:
252.2
MOL-Datei:
126453-07-4.mol
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(R)-CPP Eigenschaften

Siedepunkt:
546.7±60.0 °C(Predicted)
Dichte
1.408±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
Löslichkeit
Water: 100mM
Aggregatzustand
White crystalline powder.
pka
1.89±0.20(Predicted)
Wasserlöslichkeit
Soluble to 100 mM in water

Sicherheit

(R)-CPP Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).

Verwenden

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

Biologische Aktivität

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

(R)-CPP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

117414-78-5 D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

Downstream Produkte

(R)-CPP Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 61)Lieferanten
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
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126453-07-4()Verwandte Suche:

(+)-R-2-(2,4-Dichlorphenoxy)-propionsäure 2-(4-Chlorphenoxy)propionsure
  • (R)-CPP
  • (R)-CCP
  • R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • D-CPP
  • 3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • 3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • 3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid
  • rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid
  • rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid
  • rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid
  • [3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
  • 3-[(2R)-2-Carboxypiperazine-4-yl]propane-1-ylphosphonic acid
  • CPP (R)-
  • 2-Piperazinecarboxylic acid, 4-(3-phosphonopropyl)-, (2R)-
  • (R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid
  • (R)CPP,(R) CPP
  • 126453-07-4
  • C8H17N2O5P
  • Glutamate
  • Glutamate receptor
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