ChemicalBook
Chinese english Germany Japanese Korea

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Produkt Beschreibung

G-STROPHANTHIN Struktur
630-60-4
CAS-Nr.
630-60-4
Bezeichnung:
3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid
Englisch Name:
G-STROPHANTHIN
Synonyma:
oubain;uabaina;uabanin;QUABAIN;OUABAIN;ouabaine;ASTROBAIN;GRATIBAIN;strodival;NSC 25485
CBNumber:
CB6753829
Summenformel:
C29H44O12
Molgewicht:
584.65
MOL-Datei:
630-60-4.mol

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Eigenschaften

Schmelzpunkt:
200°C
Siedepunkt:
561.69°C (rough estimate)
Dichte
1.1941 (rough estimate)
Brechungsindex
-32 ° (C=1, H2O)
storage temp. 
Desiccate at -20°C
Löslichkeit
H2O: 10 mg/mL cold
Aggregatzustand
powder
Farbe
white
Merck 
6901

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 23/25-33
S-Sätze: 45
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS-Nr. RN3850000
8

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/25:Giftig beim Einatmen und Verschlucken.
R33:Gefahr kumulativer Wirkungen.

S-Sätze Betriebsanweisung:

S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Ouabain is a white crystalline solid.

Allgemeine Beschreibung

Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.

Reaktivität anzeigen

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].

Health Hazard

G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.

Brandgefahr

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)

Biologische Aktivität

Selective Na + , K + -ATPase inhibitor.

Sicherheitsprofil

Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes

mögliche Exposition

Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.

Enzyminhibitor

This cardiac glycoside (FW = 584.66 g/mol) from Strophanthus gratus and Acokanthera ouabaio, also calledγ-strophanthin and gratus strophanthin, selectively inhibits Na+/K+ exchanging ATPases by binding to the a-subunit near its amino terminal and to the H5-H6 hairpin region, blocking the active efflux of sodium ion as wellas the reuptake of potassium ion by blocking movement of the H5 and H6 transmembrane domains. Ouabain increases natriuresis, slows heart rate with its positive ionotropic effect, increases intracellular Ca2+, and induces hypertension. Recently, endogenous inhibitors of the Na+/K+-exchanging ATPase have been identified in adrenal cortex and brain that are stereoisomers of ouabain and possess inotropic and vasopressor activities. Hydrolysis of ouabain will yield ouabagenin and L-rhamnose. Ouabain octahydrate (FW = 728.78 g/mol) is soluble in boiling water (200 mg/mL), cold water (10 mg/mL), and ethanol (10 mg/mL at room temperature). Ouabain should be stored in the dark. Target(s): adenylate cyclase, Phycomyces blakesleeanus; H+/K+-exchanging ATPase, moderately sensitive; Na+/K+-exchanging ATPase; 4-nitrophenylphosphatase activity of Na+/K+-exchanging ATPase.

Versand/Shipping

UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

läuterung methode

It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]

Inkompatibilitäten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 47)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Hubei xin bonus chemical co. LTD
13657299721
zhangyuzhu@xhlchem.com CHINA 17424 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96512 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15882 69
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44045 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
BOC Sciences
info@bocsci.com United States 10507 65
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12342 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 24991 65
Shanghai Tauto Biotech Co., Ltd 0086-21-51320588
0086-21-51320502 export2@tautobiotech.com China 3574 66

630-60-4(3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid)Verwandte Suche:


  • (1beta,3beta,5beta,11alpha)-ahydroxy
  • (1beta,3beta,5beta,11alpha)-hydroxy
  • 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-1,5,11alpha,14,19-pentahydroxycard-20(
  • 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,(1.beta.,3.beta.,5.beta.,11.aCard-20(22)-enolide
  • card-20(22)-enolide,3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-1,5,11,14,19-penta
  • card-20(22)-enolide,3-[(6-deoxy-alpha-l-mannopyranosyl)oxy]-1,5,11,14,19-pent
  • g-strophicor
  • ouabagenin-l-rhamnosid
  • Strophanthin(quabain)
  • strophoperm
  • strophosan
  • uabaina
  • uabanin
  • 20(22),5BETA-CARDENOLID-1BETA,3BETA,5BETA,14BETA-HEXAL 3BETA-ALPHA-1-RHAMNOSIDE
  • 3-[(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)OXY]-1,5,11A,14,19-PENTAHYDROXYCARD-20(22)-ENOLIDE
  • 3-[(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)OXY]-1,5,11ALPHA-14,19-PENTAHYDROXYCARD-20(22)-ENOLIDE
  • ACOCANTHERIN
  • ACOCANTHERINE
  • QUABAIN
  • PUROSTROPHAN
  • STROPHANTHIN, G-
  • OUABAIN
  • ouabageninl-rhamnoside
  • ouabaine
  • oubain
  • rectobaina
  • solufantina
  • strodival
  • strophalen
  • GRATIBAIN 99%
  • 4-[(1R,3S,5S,10R,11R,13R,14S,17S)-1,5,11,14-tetrahydroxy-10-(hydroxyme thyl)-13-methyl-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-y l]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenant hren-17-yl]-5H-furan-2-one
  • Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, (1β,3β,5β,11α)-
  • NSC 25485
  • Ouabain (8CI)
  • 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, (1.beta.,3.beta.,5.beta.,11.aCard-20(22)-enolide
  • 1β,5,11α,14,19-Pentahydroxy-3β-(α-L-rhamnopyranosyloxy)-5β,14β-carda-20(22)-enolide
  • ASTROBAIN
  • Diveasidum
  • GRATIBAIN
  • GRATUS STROPHANTHIN
  • G-STROPHANTHIN
  • GRATUS STROPHANTHIN 99%
  • Sugars
  • Rhamnose
  • Steroids
  • Glycosides
  • Steroidglycosides
  • Biochemistry
  • Glycosides
  • Rhamnose
  • Steroidglycosides
  • Steroids
  • Sugars
  • Inhibitors
  • 3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1β,5,11α,14,19-pentahydroxy-5β,14β-card-20(22)-enolide
  • 3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1β,5,11α,14,19-pentahydroxy-5β-card-20(22)-enolide
  • 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
  • Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-
Copyright 2019 © ChemicalBook. All rights reserved