FORTIMICIN

FORTIMICIN Struktur
55779-06-1
CAS-Nr.
55779-06-1
Englisch Name:
FORTIMICIN
Synonyma:
kw-1070;XK-70-1;Astricin;astromicin;FORTIMYCIN;FORTIMICIN;ASTROMYCIN;fortimicina;Fortimycin A;antibiotickw-1070
CBNumber:
CB7116881
Summenformel:
C17H35N5O6
Molgewicht:
405.49
MOL-Datei:
55779-06-1.mol

FORTIMICIN Eigenschaften

Schmelzpunkt:
>200° (dec)
alpha 
D25 +87.5° (c = 0.1 in water)
Siedepunkt:
526.82°C (rough estimate)
Dichte
1.0897 (rough estimate)
Brechungsindex
1.7600 (estimate)
pka
13.16±0.70(Predicted)

Sicherheit

Toxizität LD50 (of the sulfate salt) in mice (mg/kg): 380 i.v.; 400 s.c. (Nara, 1977)

FORTIMICIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition

ChEBI: An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at posi ion 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is adm nistered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.

Antimicrobial activity

A pseudodisaccharide aminoglycoside produced by Micromonospora olivoasterospora. Formulated as the sulfate. Intrinsic activity is similar to that of amikacin for most groups of organisms, but activity against Ps. aeruginosa is relatively poor. It is resistant to many aminoglycoside-modifying enzymes, but is sensitive to AAC(3) and the APH(2″)/AAC(6′) bifunctional enzyme.
Peak concentrations of 10–12 mg/L were found in the blood following 200 mg intravenous or intramuscular administration to volunteers. The plasma half-life was 1.5–2 h. Over 85% of the drug was recovered in urine during the 8 h following administration.
Toxicity and side effects are similar to those observed with other aminoglycosides. Where the drug is available it is used instead of amikacin in the treatment of infections caused by susceptible organisms.

FORTIMICIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FORTIMICIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3581 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9320 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29220 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-19164747840 +86-13119157289
13119157289@163.com China 2971 58
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
info@yuhaochemical.com China 9394 52
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14059 65
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12338 58
Amatek Scientific Co. Ltd. 0512-56316828
info@amateksci.com China 28822 58

55779-06-1()Verwandte Suche:


  • 4,6,7-pentadeoxy-beta-l-lyxo-heptopyranosyl)-6-o-methyl-mino-3
  • antibiotickw-1070
  • 4-Amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol
  • XK-70-1
  • ASTROMICIN SULPHATE
  • FORTIMICIN
  • FORTIMYCIN
  • Abbott-44747:XK-70-1
  • astromicin
  • fortimicina
  • kw-1070
  • l-chiro-inositol,4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-o-(2,6-dia
  • L-chiro-Inositol, 4-amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-
  • Fortimycin A
  • 4-Amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-ehiroinositol
  • ASTROMYCIN
  • L-chiro-Inositol, 4-amino-1-[(2-aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-
  • FORTIMICIN USP/EP/BP
  • Astricin
  • 55779-06-1
  • C17H35N5O6
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