Chinese english Germany Japanese Korea

6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat

Cyproterone acetate Struktur
427-51-0
CAS-Nr.
427-51-0
Bezeichnung:
6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat
Englisch Name:
Cyproterone acetate
Synonyma:
ANDROCUR;CYPROSTAT;CIPROTERONE ACETATE;SH-714;nsc-81430;Cyproviron;cyprosteroneacetate;CYPROTERONE ACETATE;CYPROFERONE ACETATE;cyproteron-racetate
CBNumber:
CB7338955
Summenformel:
C24H29ClO4
Molgewicht:
416.94
MOL-Datei:
427-51-0.mol
Request For Quotation

6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Eigenschaften

Schmelzpunkt:
200-201°C
Siedepunkt:
528.8°C (rough estimate)
Dichte
1.0677 (rough estimate)
Brechungsindex
1.4429 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
Farbe
White to Off-White
maximale Wellenlänge (λmax)
281nm(MeOH)(lit.)
Merck 
14,2774
InChIKey
UWFYSQMTEOIJJG-KIXORDEXNA-N
SMILES
C[C@@]12C(=CC(=O)[C@@H]3C[C@H]13)C(Cl)=C[C@@]1([H])[C@]3([H])CC[C@@](C(=O)C)(OC(=O)C)[C@@]3(C)CC[C@]21[H] |&1:1,6,8,12,14,18,26,30,r|
EPA chemische Informationen
3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- (427-51-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 20/21/22-40-36/37/38
S-Sätze: 22-36-26
WGK Germany  3
RTECS-Nr. GZ2230000
HS Code  29372900
Giftige Stoffe Daten 427-51-0(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Cyproterone acetate (CPA) is an androgen receptor antagonist. It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg. CPA (0.3 μM) also induces apoptosis in primary adult female rat hepatocytes. Formulations containing cyproterone acetate have been used in the treatment of androgenization in females.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Cyproterone acetate (CPA) has been shown to exert gestagenic and glucocorticoid effects. Because it inhibits the negative diencephalic pituitary testicular feedback system, it lowers luteinizing hormone (LH) and testosterone production and plasma levels. cyproterone acetate is both an anti-androgen and a progestogen. CPA is used in combined birth control pills, in the treatment of androgen-dependent skin and hair conditions such as acne (Combined with estrogen), seborrhea, excessive hair growth, and scalp hair loss, high androgen levels, in transgender hormone therapy, to treat prostate cancer, to reduce sex drive in sex offenders or men with paraphilias or hypersexuality, to treat early puberty, and for other uses. It is used both at low doses and at higher doses.

Indications

Cyproterone acetate is a progestational antiandrogen that blocks androgen receptor binding and suppresses androgen-sensitive tissues. It is available in a topical form in Europe for the treatment of hirsutism.

6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Essigsure

Downstream Produkte

6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 410)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
 sean.lv@synzest.com China 323 58
Wuhan Haorong Biotechnology Co.,ltd 		+8618565342920
 sales@chembj.net China 269 58
Hebei Anlijie Biotechnology Co., Ltd 		+8619031013551
 ably@aljbio.com China 177 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845
 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22968 58

427-51-0(6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat)Verwandte Suche:

2-Methoxy-1-methylethylacetat Methylacetat 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat Leuprorelin acetate 2-Ethoxy-ethylacetat Vinylacetat Glatiramer acetate POLY(VINYL ACETATE) 2-Butoxy-ethylacetat Isopropylacetat Natriumacetat Ethylacetat n-Butylacetat 3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure Chlormadinonacetat ACETATE Cyproterone (7E,9Z)-Dodecadienyl acetat
  • cyprosteroneacetate
  • 1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio
  • 1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat
  • 1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate
  • 17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio
  • 20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3
  • 6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4
  • 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
  • 6-chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup6)-progesteroneaceta
  • 6-chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesteroneacetate
  • 6-chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dioneacet
  • 6-chloro-delta(sup6)-1,2-alpha-methylene-17-alpha-hydroxyprogesteroneacetat
  • CYPROTERONE ACETATE
  • CYPROFERONE ACETATE
  • 6-CHLORO-1BETA,2BETA-DIHYDRO-17-HYDROXY-3'H-CYCLOPROPA[1,2]-PREGNA-1,4,6-TRIENE-3,20-DIONE ACETATE
  • 6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
  • 4,6-PREGNADIEN-6-CHLORO-1-ALPHA, 2-ALPHA-METHYLENE-17-OL-3,20-DIONE ACETATE
  • cyproterone17-alpha-acetate
  • cyproteron-racetate
  • nsc-81430
  • Cyproterone Acetate BP2000,EP2000
  • 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
  • Androcur, Cyprostat
  • 3H-Cyclopropa1,2pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)-
  • 6-Chloro-1α,2α-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
  • CyproteroneAcetateedmfep5
  • CyproteroneAcetateEdmf
  • 6-Chloro-1β,2β-dihydro-17-hydroxy-3μH-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
  • Androcurone acetate
  • SH-714
  • Cyproterone acetate(Androcur)
  • Cyproviron
  • (1β,2β)-17-(acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
  • Cyproterone acetate for peak identification
  • * Color Pronk (cyproterone)
  • Cyproterone D3 Acetate
  • Cyproterone acetate, 98%, an androgen receptor (AR) antagonist
  • Cyproterone acetate CRS
  • Cyproterone acetate for peak identification CRS
  • Cyproterone Acetate >
  • Cyproterone 17-O-acetate
  • 6-Chloro-3,20-dioxo-1β,2β-dihydro-3′H-cyclopropa-[1,2]pregna-1,4,6-trien-17-yl acetate
  • (1aR,5aR,5bS,8R,8aS,9aS,9bS,9cS)-8-Acetyl-4-chloro-8a,9b-dimethyl-2-oxo-1a,2,5a,5b,6,7,8,8a,9,9a,9b,9c-dodecahydro-1H-cyclopropa[a]pentaleno[1,2-h]naphthalen-8-yl acetate
  • Cyproterone acetate USP/EP/BP
  • Cyproterone Acetate-13C,d3
  • Cyproterone acetateQ: What is Cyproterone acetate Q: What is the CAS Number of Cyproterone acetate Q: What is the storage condition of Cyproterone acetate Q: What are the applications of Cyproterone acetate
  • Cyproterone acetate (C3283000)
  • Cyproterone Acetate D3Q: What is Cyproterone Acetate D3 Q: What is the CAS Number of Cyproterone Acetate D3 Q: What is the storage condition of Cyproterone Acetate D3 Q: What are the applications of Cyproterone Acetate D3
  • CIPROTERONE ACETATE
  • ANDROCUR
  • CYPROSTAT
  • Cyproterone acetate API
  • Cyproterone acetate chloride
  • Cyproterone (+)-bitartrate salt
  • 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1β,2β)-
  • 4, 6-PREGNADIEN-6-CHLORO-1α, 2α-METHYLENE-17-OL-3, 20-DIONE ACETATE
  • (2aR,3aS,3bS,3cS,5aS,6R,8aS,8bR)-6-acetyl-10-chloro-3b,5a-dimethyl-2-oxo-2,2a,3,3a,3b,3c,4,5,5a,6,7,8,8a,8b-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-6-yl acetate
  • 427-51-0
Copyright 2019 © ChemicalBook. All rights reserved