Corticosteron
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- CAS-Nr.
- 50-22-6
- Bezeichnung:
- Corticosteron
- Englisch Name:
- CORTICOSTERONE
- Synonyma:
- 21-Dihydroxyprogesterone;NSC-9705;compoundb;Compound B;Azlocilline;KENDALL'S 'B';Corticosteron;CORTICOSTERONE;Reichstein's B;17-Deoxycortisol
- CBNumber:
- CB7418589
- Summenformel:
- C21H30O4
- Molgewicht:
- 346.47
- MOL-Datei:
- 50-22-6.mol
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Corticosteron Eigenschaften
- Schmelzpunkt:
- 179-183 °C(lit.)
- alpha
- D15 +223° (c = 1.1 in alc)
- Siedepunkt:
- 401.19°C (rough estimate)
- Dichte
- 1.0413 (rough estimate)
- Brechungsindex
- 1.4430 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- -20°C
- Löslichkeit
- Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated)
- Aggregatzustand
- White to tan crystalline powder
- Farbe
- White to Pale Yellow
- Optische Aktivität
- [α]20/D +223±3°, c = 1% in ethanol
- Wasserlöslichkeit
- 240.5mg/L(37 ºC)
- Merck
- 2538
- BRN
- 2339601
- Stabilität:
- Stable, but light sensitive. Incompatible with strong oxidizing agents.
- CAS Datenbank
- 50-22-6(CAS DataBase Reference)
- EPA chemische Informationen
- Corticosterone (50-22-6)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi,N,Xn,T,F |
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| R-Sätze: |
43-40-39/23/24/25-23/24/25-11 |
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| S-Sätze: |
36-22-45-36/37-16 |
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| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
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| WGK Germany |
3 |
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| RTECS-Nr. |
GM7650000 |
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| HS Code |
29372900 |
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| Toxizität |
An adrenocortical steroid with modest glucocorticoid
and mineralocorticoid activity. It is the primary glucocorticoid
in the rat. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Corticosteron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-
wake cycle.
Chemische Eigenschaften
white to light yellow powder
Verwenden
Corticosterone: HBC complex has been used:
- in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
- to induce acute stress in mice
- in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Definition
ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan
s.
Allgemeine Beschreibung
Corticosterone is a corticosteroid and aldosterone precursor produced in the adrenal glands. Serum corticosterone levels are measured by LC-MS/MS for newborn screening and diagnosis of 11-hydroxylase deficiency.
Biologische Aktivität
Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.
läuterung methode
Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]
Corticosteron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Corticosteron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 266)Lieferanten
50-22-6(Corticosteron)Verwandte Suche:
Epinephrin
myo-Inosit
Fludrocortison-21-acetat
9-Fluor-11β,21-dihydroxy-16α,17-(isopropylidendioxy)pregn-4-en-3,20-dion
Hydrocortison-21-(hydrogensuccinat)
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat
Fludroxycortid
Hydrocortison
Hydrocortison-21-acetat
Pregn-4-en-3,20-dion, 11,17-Dihydroxy-21-(phosphonooxy)-, Dinatriumsalz, (11β)-
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-valerat
11β,21-Dihydroxypregn-4-en-3,20-dion-21-acetat
Hydrocortison-21-(natriumsuccinat)
Corticosteron
11β,17,21-Trihydroxypregn-4-en-3,20-dion-21-octanoat
11β,18,21-Trihydroxypregn-4-en-3,20-dion
11β,17,21-Trihydroxypregn-4-en-3,20-dion-21-cyclopentanpropionat
- 4-PREGNENE-11BETA,21-DIOL-3,20-DIONE
- 11BETA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
- 11,12-dihydroxyprogesterone
- 11BETA,21-DIHYDROXY-PROGESTERONE
- 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
- 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE
- (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
- KENDALL'S 'B'
- KENDALL'S COMPOUND B
- KENDALL'S COMPOUND ''B''
- KENDALL'S COMPOUND 'B'
- CORTICOSTERONE
- DELTA4-PREGNEN-11BETA, 21-DIOL-3, 20-DIONE
- 11β,21-Dihydroxy-4-pregnene-3,20-dione
- 4-Pregnene-11β,21-diol-3,20-dione
- CORTICOSTERONE CRYSTALLINE
- CORTICOSTERONE VETRANAL, 100 MG
- (8R,9S,10S,11R,13S,14R,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- CORTICOSTERONE(RG)
- 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendalls Compound B, Reichsteins Substance H
- (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- (8S,9S,10R,11S,13S,14S,17S)-17-glycoloyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
- Corticosterone,11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
- 4-Pregnen-11,21-diol-3,20-dione-d8
- (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- Corticosterone solution
- corticosterone solution,100ppm
- 11,21-Dihydroxypregn-4-ene-3,20-dione
- 11,21-Dihydroxyprogesterone
- 11-beta,21-Dihydroxypregn-3,20-dione
- 11-beta,21-dihydroxy-pregn-4-ene-20-dione
- 11-Hydroxycorticoaldosterone
- 17-Deoxycortisol
- 21-dihydroxy-20-dion(11-beta)-pregn-4-ene-11
- Compound B
- compoundb
- Corticosteron
- NSC-9705
- Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-
- Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-
- Reichstein's B
- REICHSTEIN'S SUBSTANCE H
- REICHSTEIN'S SUBSTANCE ''H''
- REICHSTEIN'S SUBSTANCE 'H'
- 4-PREGNEN-11B,21-DIOL-3,20-DIONE
- 4-PREGNEN-11-BETA, 21-DIOL-3,20-DIONE
- Corticosterone>
- Corticosterone Corticosterone
- CORTICOSTERONE USP/EP/BP
- Pregn-4-ene-3,20-dione,11,21-dihydroxy-, (11b)-
- 11β,21-Dihydroxyprogesterone
- Azlocilline
- Corticosterone - CAS 50-22-6 - Calbiochem
- 21-Dihydroxyprogesterone
- Corticisterone Corticosteroid Raw Powder
- Corticosterone- -d4
