Hydrocortison-21-acetat
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- CAS-Nr.
- 50-03-3
- Bezeichnung:
- Hydrocortison-21-acetat
- Englisch Name:
- Hydrocortisone acetate
- Synonyma:
- HYDROCORTISONE 21-ACETATE;CORTISOL ACETATE;CORTISOL 21-ACETATE;Cortef;Epifoam;Cortifoam;Fernisone;Carmol HC;Hc45;Mysone
- CBNumber:
- CB7196805
- Summenformel:
- C23H32O6
- Molgewicht:
- 404.5
- MOL-Datei:
- 50-03-3.mol
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Hydrocortison-21-acetat Eigenschaften
- Schmelzpunkt:
- 223 °C (dec.)(lit.)
- Siedepunkt:
- 446.1°C (rough estimate)
- alpha
- D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
- Dichte
- d420 1.289
- Brechungsindex
- 1.4593 (estimate)
- Flammpunkt:
- 223°C
- storage temp.
- 0-6°C
- Löslichkeit
- Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
- pka
- 12.42±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- Insoluble in water.
- Decomposition
- 223 ºC
- Merck
- 14,4787
- BRN
- 2066841
- Stabilität:
- Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
- LogP
- 2.190
- CAS Datenbank
- 50-03-3(CAS DataBase Reference)
- NIST chemische Informationen
- Hydrocortisone acetate(50-03-3)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,T |
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| R-Sätze: |
63-10-45 |
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| S-Sätze: |
36/37-45-53 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
GM8960000 |
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| HS Code |
29372100 |
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| Toxizität |
LD50 intraperitoneal in mouse: 2300mg/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H373 |
Kann die Organe schädigen bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Hydrocortison-21-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Verwenden
Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).
läuterung methode
The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]
Hydrocortison-21-acetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Hydrocortison-21-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 602)Lieferanten
50-03-3(Hydrocortison-21-acetat)Verwandte Suche:
Hydrocortison
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat
Natriumacetat
Glatiramer acetate
Ethylacetat
Ammoniumacetat
POLY(VINYL ACETATE)
Hydrocortison-21-(natriumsuccinat)
Vinylacetat
CELLULOSE ACETATE
Hydrocortison-21-(hydrogensuccinat)
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat-21-propionat
Hydrocortamat
ACETATE
Cortison
11β,17,21-Trihydroxypregn-4-en-3,20-dion-21-cyclopentanpropionat
11β,17,21-Trihydroxypregn-4-en-3,20-dion-21-octanoat
Cortison-21-acetat
- (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
- 11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
- 11-beta,17-alpha-dihydroxy-21-acetoxypregesterone
- 11beta17alpha-Dihydroxy-21-acetoxypregesterone
- 17-alpha-hydrocorticosterone21-acetate
- 17alpha-Hydrocorticosterone-21-acetate
- 17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11
- 17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11
- 17-hydroxy-corticosteron21-acetate
- 20-dione,11-beta,17,21-trihydroxy-pregn-4-ene-21-acetate
- 21-acetoxy-11-beta,17-alpha-dihydroxypregn-4-ene-3,20-dione
- 21-Acetoxy-11beta17alpha-dihydroxypregn-4-ene-3,20-dione
- Abbocort
- Acetate-as
- Aceto-Cort
- Anusol-HC
- Bambicort
- Berlison F
- berlisonf
- Corticosterone, 17-hydroxy-, 21-acetate
- Cortril acetate
- Cortril acetate-AS
- cortrilacetate
- cortrilacetate-as
- Efcolin
- Eye-Cort
- Hc45
- Hycortole acetate
- hycortoleacetate
- Hydrocal
- Hydrocortisat
- Hydrocortistab
- Hydrosone
- Hydroxycorticosterone acetate
- hydroxycorticosteroneacetate
- Hysone-A
- Isopto-Hydrocortisone
- Lenirit
- Mysone
- NSC 741
- 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
- 4-PREGNEN-11BETA,17ALPHA,21-TETROL-3,20-DIONE 21-ACETATE
- 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE
- Hydrocortisone Acetate BP/USP/EP
- HYDROCORTISONE ACETATE, PH EUR
- HYDROCORTISONE ACETATE USP
- HYDROCORTISON 21-ACETATE VETRANAL, 250 M
- 11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-acetate
- HYDROCORTISONEACETATE,MICRONIZED,USP
- 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
- 21-Acetoxy-11β,17-dihydroxypregn-4-en-3,20-dione
- 21-Acetoxy-11β,17-dihydroxypregn-4-ene-3,20-dione
- 21-Acetoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione
- Cortisol acetate (6CI)
- Cortisol, 21-acetate (7CI, 8CI)
- Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)-
- Hydrocortisone acetate usp 36
- Hydrocortisone-AcetatePuriss
