DS-437

1674364-87-4

CAS-Nr.: 1674364-87-4

Englisch Name:: DS-437

Synonyma:: DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-

CBNumber:: CB74669958

Summenformel:: C15H23N7O4S

Molgewicht:: 397.45

MOL-Datei:: 1674364-87-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 16

DS-437 Eigenschaften

Dichte: 1.71±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)

pka: 13.13±0.70(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

RIDADR	UN 2811 6.1 / PGIII

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H301	Giftig bei Verschlucken.	Akute Toxizität oral	Kategorie 3	Achtung	src="/GHS06.jpg" width="20" height="20" />	P264, P270, P301+P310, P321, P330,P405, P501

Sicherheit

DS-437 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC₅₀s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC₅₀s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185^erbB2/neu antibody 4D5.

Verwenden

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Biochem/physiol Actions

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

DS-437 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

DS-437 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 16)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29778	58
InvivoChem	13549236410	sales@invivochem.cn	China	6755	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	18779	58

DS-437
DS-437 (DS437
Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
DS-437 >=98% (HPLC)
1674364-87-4
C15H23N7O4S