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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Struktur
105628-72-6
CAS-Nr.
105628-72-6
Englisch Name:
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Synonyma:
Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;Hydroxyfasudil, 10 mM in DMSO;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
CBNumber:
CB7847446
Summenformel:
C14H17N3O3S
Molgewicht:
307.37
MOL-Datei:
105628-72-6.mol
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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Eigenschaften

storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
Soluble in DMSO
Aggregatzustand
Solid
Farbe
White to off-white
InChI
InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChIKey
ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C(S(N3CCCNCC3)(=O)=O)=CC=C2)C=CN1
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Toxizität mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 103)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29845 58
Standardpharm Co. Ltd. 		86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626
 eric@witopchemical.com China 23541 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750
 info@finetechnology-ind.com China 9629 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354;
support@targetmol.com United States 39035 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490
 info@gihichemicals.com China 49936 58

105628-72-6()Verwandte Suche:

Isochinolin Chinaldin Chinolin-8-sulfonsure 1,3-Dibrompropan 2-Methylnaphthalin 1-Methyl-naphthalin Chinolin-5-sulfonsure 8-Methylchinolin Chinolin 1-Hydroxyisochinolin
  • 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one
  • HYDROXYFASUDIL;HA-1100;HA 1100;HA1100
  • 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
  • 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-
  • Ha 1100
  • Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine
  • 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride
  • HA 1100 HYDROCHLORIDE
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol
  • Fasudil Impurity L
  • 1-[(1,2-DIHYDRO-1-OX
  • 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
  • Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride
  • HA-1100;HA 1100;HA1100
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
  • HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase
  • Fasudil Impurity 5
  • Hydroxyfasudil, 10 mM in DMSO
  • 105628-72-6
  • C14H17N3O3S
  • Angiogenesis and Metastasis
  • Intracellular signaling
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