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Chinolin Produkt Beschreibung

CAS-Nr.91-22-5
Bezeichnung:Chinolin
Englisch Name:Quinoline
Synonyma:
B 500;b-500;Leucol;Leukol;Quinolin;CHINOLIN;Benzazine;Chinoline;FEMA 3470;QUINOLINE
CBNumber:CB2331254
Summenformel:C9H7N
Molgewicht:129.16
MOL-Datei:91-22-5.mol
Chinolin physikalisch-chemischer Eigenschaften
Schmelzpunkt:: −17-−13 °C(lit.)
Siedepunkt:: 113-114 °C11 mm Hg(lit.)
Dichte: 1.093 g/mL at 25 °C(lit.)
Dampfdichte: 4.5 (vs air)
Dampfdruck: 0.07 mm Hg ( 20 °C)
Brechungsindex: n20/D 1.625(lit.)
Flammpunkt:: 214 °F
storage temp. : Store below +30°C.
Löslichkeit: 6g/l
Aggregatzustand: Liquid
pka: 4.9(at 20℃)
Farbe: Purple to dark grey
Geruch (Odor): Strong, unpleasant.
PH: 7.3 (5g/l, H2O, 20℃)
Explosionsgrenze: 1.2-7%(V)
Wasserlöslichkeit: slightly soluble
Sensitive : Light Sensitive & Hygroscopic
Merck : 14,8068
BRN : 107477
Stabilität:: Stable. Incompatible with strong acids, strong oxidizing agents. May discolour on exposure to light. Hygroscopic - protect from moisture. Reacts violently and unpredictably with some materials, especially strong oxidizing agents.
InChIKey: SMWDFEZZVXVKRB-UHFFFAOYSA-N
CAS Datenbank: 91-22-5(CAS DataBase Reference)
NIST chemische Informationen: Quinoline(91-22-5)
EPA chemische Informationen: Quinoline(91-22-5)
Sicherheit
Kennzeichnung gefährlicher: Xn,N,T
R-Sätze:: 21/22-38-41-68-40-37/38-51/53-36/38-45
S-Sätze:: 26-36/37/39-36-23-61-45-53
RIDADR : UN 2656 6.1/PG 3
WGK Germany : 2
RTECS-Nr.: VA9275000
F : 8
Selbstentzündungstemperatur: 896 °F
TSCA : Yes
HazardClass : 6.1
PackingGroup : III
HS Code : 29334900
Giftige Stoffe Daten: 91-22-5(Hazardous Substances Data)
Toxizität: LD50 orally in rats: 460 mg/kg (Smyth)

Chinolin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE HYGROSKOPISCHE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH. VERFäRBT SICH BRAUN NACH EINWIRKUNG VON LICHT.
CHEMISCHE GEFAHREN
Die Substanz zersetzt sich beim Erhitzen und beim Verbrennen unter Bildung von giftigen Rauchen mit Stickoxiden. Reagiert mit starken Oxidationsmitteln, Säuren und Anhydriden.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt.
MAK nicht festgelegt.
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein , viel schneller jedoch beim Versprühen oder Dispergieren.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Haut.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf die Leber. Möglicherweise krebserzeugend für den Menschen.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzgerät mit Filter für organische Gase und Dämpfe entsprechend der Arbeitsplatzkonzentration des Stoffes. NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.
R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R38:Reizt die Haut.
R41:Gefahr ernster Augenschäden.
R68:Irreversibler Schaden möglich.
R40:Verdacht auf krebserzeugende Wirkung.
R37/38:Reizt die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Aussehen Eigenschaften
C9H7N. Bräunliche Flüssigkeit mit unangenehmem Geruch.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken. Reizt die Augen.
Resorption führt zu Atemdämpfung, Herz-Kreislaufstörungen und Krämpfen.
LD50 (oral, Ratte): 331 mg/kg
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.
Verhalten im Gefahrfall
Dämpfe nicht einatmen.
Mit flüssigkeitsbindendem Material, z.B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Schaum, Pulver.
Brennbar. Im Brandfall Entstehung nitroser Gase möglich.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Reichlich Wasser trinken. Erbrechen auslösen. Sofort Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung
Als halogenfreie, organische Lösemittelabfälle.
Beschreibung
Quinoline is a colourless hygroscopic liquid with characteristic odour. On exposure to light, it turns brown in colour. Quinoline decomposes on heating, and on burning produces toxic fumes including nitrogen oxides. Quinoline reacts with strong oxidants, acids, and anhydrides. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Quinoline is combustible. It gives off irritating or toxic fumes (or gases) in a fire. Quinoline is incompatible with strong acids, oxidisers, dinitrogen tetroxide, linseed oil, thionyl chloride, maleic anhydride, and perchromates and reacts violently with most incompatibles. Quinoline is used extensively in the manufacturing of dyes, preparation of hydroxyquinoline sulphate and niacin, as a solvent for resins and terpenes, and as an intermediate in the manufacture of other products.
Quinoline is used mainly as an intermediate in the manufacture of other several products, as a catalyst, as a corrosion inhibitor, in metallurgical processes, in the manufacture of dyes, as a preservative for anatomical specimens, in polymers and agricultural chemicals, and as a solvent for resins and terpenes. Quinoline is also used as an anti-malarial medicine. Because of its solubility in water, quinoline has significant potential for mobility in the environment, which may promote water contamination. Potential exposure to quinoline also occurs from the inhalation of cigarette smoke. Quinoline breaks down quickly in the atmosphere and water.
Chemische Eigenschaften
Quinoline is a colorless liquid with a penetrating amine odor. Turns brown on exposure to light.
Chemische Eigenschaften
colourless to brown liquid
Chemische Eigenschaften
Quinoline has a heavy, penetrating and nauseating, yet sweet odor of good tenacity.
Occurrence
Quinoline was discovered in coal tar distillate in 1834 by Runge. It is released to the environment through natural combustion processes and has been isolated from air particulates (Dong et al 1977). Quinoline may be a significant aqueous byproduct of synthetic fuel production (shale oil, coal processing) and from wood preservation production and use facilities. Small amounts also have been detected in tobacco smoke (Schmeltz and Hoffmann 1977).
Verwenden
Preserving anatomical specimens; manufac- ture of quinolinol sulfate; niacin and copper-8- quinolinolate; flavoring.
Verwenden
Quinoline is used in the manufacture of dyesand hydroxyquinoline salts; as a solvent forresins and terpenes; and therapeutically as anantimalarial agent. It occurs in coal tar insmall amounts.
Definition
ChEBI: The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.
Vorbereitung Methode
Quinoline may be synthesized by heating aniline with glycerol and nitrobenzene in sulfuric acid (Skraup method) or by reacting aniline, acetaldehyde, and a formaldehyde hemiacetal (Windholz et al 1983). Commercial production is by isolation from coal tar with greater than 100,000 lbs being produced in 1977. Production of refined quinoline has almost ceased due to low demand (Parris et al 1983).
Definition
A colorless two-ring heterocyclic compound with an unpleasant odor, which acts as a base and forms salts with acids. First made from the alkaloid quinine, it is found in bone oil and coal tar and used for making drugs and dyestuffs.
Definition
quinoline: A hygroscopic unpleasant-smelling colourless oily liquid,C9H7N; b.p. 240°C. Its molecules consistof a benzene ring fused to a pyridinering. It occurs in coal tar andbone oil, and is made from phenylamineand nitrobenzene. Quinolineis a basic compound, forming saltswith mineral acids and forming quaternaryammonium compounds withhaloalkanes. It is used for makingmedicines and dyes. In quinoline, thenitrogen atom is one atom awayfrom the position at which the ringsare fused. In an isomer, isoquinoline,the nitrogen atom is positioned twoatoms away from the fused ring.
Aroma threshold values
Detection: 710 ppb
Taste threshold values
Taste characteristics at 2 to 10 ppm: earthy, musty, nutty, coumarinic with a chemical nuance.
Allgemeine Beschreibung
A colorless liquid with a peculiar odor. Slightly denser than water. Contact may irritate to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reaktionen
Hygroscopic. Soluble in water.
Reaktivität anzeigen
Quinoline is hygroscopic. Quinoline absorbs as much as 22% water. Quinoline is sensitive to light and moisture. Quinoline darkens on storage. Quinoline is a weak base. A potentially explosive reaction may occur with hydrogen peroxide. Quinoline reacts violently with dinitrogen tetraoxide. Quinoline also reacts violently with perchromates. Quinoline is incompatible with (linseed oil + thionyl chloride) and maleic anhydride. Quinoline is also incompatible with strong oxidizers and strong acids. Quinoline can be unpredictably violent. Quinoline dissolves sulfur, phosphorus and arsenic trioxide. Quinoline may attack some forms of plastics. Quinoline is a preparative hazard.
Health Hazard
Vapors are irritating to nose and throat and may cause headaches, dizziness, and nausea if inhaled. Ingestion causes irritation of mouth and stomach; vomiting may occur. Contact with eyes or skin causes irritation.
Health Hazard
There is little information in the publishedliterature on the toxic properties of quinoline.The acute toxicity is moderate in rodentsfrom oral and dermal administration. Thereported oral LD50 values in rats showinconsistent values ranging between 300 and500 mg/kg. Its irritant action was mild onrabbits’ skin and severe in the animals’ eyes.Quinoline exhibited carcinogenicity inrats and mice, causing liver cancer. There isno evidence of its carcinogenicity in humans.It tested positive to the histidine reversion–Ames test for mutagenicity.
Health Hazard
No industrial injuries from quinoline exposure have been reported. Handling precautions similar to those taken for pyridine are recommended (EOHS 1971).
Clinical signs of toxicity include lethargy, respiratory distress, and coma; cause of death is respiratory paralysis. Quinoline is a skin and eye irritant; it may cause permanent corneal injury (EOHS 1971).
Routine occupational exposure to quinoline probably constitutes low risk for acute toxicity. Long-term exposure to low concentrations may increase cancer risk.
Brandgefahr
Flash Point (°F): 225 ℃; Flammable Limits in Air (%): No data; Fire Extinguishing Agents: Water, dry chemical, foam, or carbon dioxide; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Toxic oxides of nitrogen form in fires; Behavior in Fire: Exposure to heat can result in pressure build-up in closed containers, resulting in bulging or even explosion; Ignition Temperature (°F): 896; Electrical Hazard: No data; Burning Rate: 4.1 mm/min.
Chemische Reaktivität
Reactivity with Water No reaction; Reactivity with Common Materials: Attacks some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Industrielle Verwendung
Quinoline is used as a solvent for resins and terpenes. It also is used as an antimalarial, an antioxidant, a catalyst and as an intermediate in the manufacture of various products (Parris et al 1983).
Sicherheitsprofil
Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. Mutation data reported. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. It can cause retinitis sdar to that caused by naphthalene but without causing opacity of the lens. Combustible when exposed to heat or flame. Its preparation has caused many industrial explosions. Potentially explosive reaction with hydrogen peroxide. Violent reaction with dmtrogen tetraoxide, perchromates. Incompatible with linseed oil + thionyl chloride, maleic anhydride, Unpredctably violent. When heated to decomposition it emits toxic fumes of NOx.
mögliche Exposition
In manufacture of quinoline deriva- tives (dyes and pesticides); in synthetic fuel manufacture. Occurs in cigarette smoke.
Erste Hilfe
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxy- gen if breathing is difficult. Remove and isolate contami- nated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmo- nary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Environmental Fate
biodegradative processes occur under aerobic conditions. Anaerobic degradation is minimal (Mill et al 1981). Breakdown of quinoline in natural waters has been correlated with bacterial concentration (Rogers et al 1984). Adsorption was high in acidic soils (pH<6) and low in basic soils (pH>7). The presence of pyridine decreased quinoline adsorption on acidic, but not basic, soils. Sorption did not correlate with organic carbon or clay content (Felice et al 1984). Soil bacteria have been grown with quinoline as the sole carbon source (Grant and Al-Najjar 1976). Quinoline did not bioconcentrate to a significant extent in fathead minnows (Southworth et al 1980).
Versand/Shipping
UN2656 Quinoline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
Dry quinoline with Na2SO4 and distil it from zinc dust in a vacuum. It has also been dried by boiling with acetic anhydride, then fractionally distilled. Calvin and Wilmarth [J Am Chem Soc 78 1301 1956] cooled redistilled quinoline in ice and added enough HCl to form its hydrochloride. Diazotization removed aniline, the diazo compound being broken down by warming the solution to 60o. Non-basic impurities were removed by ether extraction. Quinoline was then liberated by neutralising the hydrochloride with NaOH, then dried with KOH and fractionally distilled at low pressure. Addition of cuprous acetate (7g/L of quinoline) and shaking under hydrogen for 12hours at 100o removed impurities due to the nitrous acid treatment. Finally the hydrogen was pumped off, and the quinoline was distilled. Other purification procedures depend on conversion to the phosphate (m 159o, precipitated from MeOH solution, filtered, washed with MeOH, then dried at 55o) or the picrate (m 201o) which, after recrystallisation, were reconverted to quinoline. The method using the picrate [Packer et al. J Am Chem Soc 80 905 1958] is as follows: quinoline is added to picric acid dissolved in the minimum volume of 95% EtOH, giving yellow crystals which were washed with EtOH, air-dried and crystallised from acetonitrile. These were dissolved in dimethyl sulfoxide (previously dried over 4A molecular sieves) and passed through a basic alumina column, onto which the picric acid is adsorbed. The free base in the effluent is extracted with n-pentane and distilled under vacuum. Traces of solvent can be removed by vapour-phase chromatography. [Moonaw & Anton J Phys Chem 80 2243 1976.] The ZnCl2 and dichromate complexes have also been used [Cumper et al. J Chem Soc 1176 1962]. [Beilstein 20 H 339, 20 I 134, 20 II 222, 20 III/IV 3334, 20/7 V 276.]
Inkompatibilitäten
Reacts, possibly violently, with strong oxidants, strong acids; perchromates, nitrogen tetroxide; and maleic anhydride. Keep away from moisture, steam, and light. Contact with hydrogen peroxide may cause explosion. Unpredictably violent, this substance has been the source of various plant accidents.
Waste disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Chinolin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Isochinolin Teer, Kohlen- Destillate (Kohlenteer)
Downstream Produkte
Chinolin-2-amin Indol-5-ylamin 4-Nitrochinolin-N-oxid Thiaminnitrat Chinolin-3-carbonitril p-Vinylphenol Chinolin-2-carbonitril Natrium-3-hydroxy-4-[(1-hydroxy-2-naphthyl)azo]-7-nitronaphthalin-1-sulfonat 2-Chinolon Oxin-kupfer 3-Aminochinuclidindihydrochlorid Pyridin-2,3-dicarbonsure Chinolin-2-carbonsure 2-Phenylchinolin Ethyl-N-(2-ethoxy-1,2-dihydrochinolin)carboxylat 2-Methoxy-4-vinylphenol Chinolin-8-sulfonylchlorid 8-Hydroxychinolin Thiaminhydrochlorid 1-Hexylisocyanat
Chinolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 232)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21922 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684info@tnjchem.com China 1751 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20580 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093export@haihangchem.com CHINA 4660 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409orders@qcchemical.com United States 8409 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 734 58
 
91-22-5(Chinolin)Verwandte Suche:
Toluol Furan Pyridin Chinolin-4-ol Isochinolin Picolinic acid chromium(III) salt 4-Methylpyridin Piperidin Pyridin-2,3-dicarbonsure Salazosulfapyridin 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine 6-Hydroxy-2(1H)-3,4-dihydroquinolinone 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthrolin 3,4,7,8-Tetramethyl-1,10-phenanthrolin 4,7-Dimethyl-1,10-phenanthrolin 4,7-Diphenyl-1,10-phenanthroliniumdi(natriosulfonat) 4,7-Diphenyl-1,10-phenanthrolin 1,10-Phenanthrolin-4,7-diol
Quinoline,Certified Quinoline, 96+% Quinoline (8CI,9CI) Quinoline,96+%Assay)Liquid Quinoline, synthetic, 99% QUINOLINE=CHINOLIN QUINOLINE,REAGENT QUINOLINE (ACS GRADE) QUINOLINE 97.5 % QUINOLINE 98.5 % Quinoline(95%) 1-Benzazine, 2,3-Benzopyridine chinolin(czech) Chinoline Quinoline, 99%, synthetic Benzazine 1-Benzazine 2,3-Benzopyridine 1-Azanaphthalene Benzo[b]pyridine Quinoline, 96% 500ML Quinoline, synthetic, 99% 100GR Quinoline, synthetic, 99% 500GR Quinoline, synthetic, 99% 5GR 8-bromo-5-fluoro-2-(trifluoromethyl)- Quinoline, 99%, redistilled, AcroSeal QUINOLINE FOR SYNTHESIS 250 ML QUINOLINE FOR SYNTHESIS 1 L QUINOLINE FOR SYNTHESIS 5 ML QUINOLINE FOR SYNTHESIS 49 KG Quinoline reagent grade, 98% Leucol Leukol Quinolin USAF ek-218 usafek-218 BENZO[B]PYRIDINE CHINOLIN FEMA 3470 2,3-BENZOPYRIDINE 1-BENZAZINE 1-AZANAPHTHALENE AKOS 91715 QUINOLINE QUINOLINE-PURE QUINOLINE-TECH CHINOLIN 99+% QUINOLINE 97+% QUINOLINE, 98+% QuinolineForSynthesis 91-22-5 kuinoline Quinoline Yellow powder DATP 100MM SOL'N PH7.0 Isoquinoline Impurity 1 Quinoline analogue -C6H4CHCHCHN 1-Benzaine 1-Benzine ai3-01241 B 500
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