Polyhexamethyleneguanidine phosphate

Polyhexamethyleneguanidine phosphate Struktur
89697-78-9
CAS-Nr.
89697-78-9
Englisch Name:
Polyhexamethyleneguanidine phosphate
Synonyma:
PHMG-P;PHMG phosphate;POLYHEXAMETHYLENE GUANIDINE PHOSPHATE;PHMG phosphate/ Polyhexamethyleneguanidine phosphate;Poly(iminoimidocarbonyliminohexamethylene) phosphate
CBNumber:
CB81014693
Summenformel:
C21H45N9X2.3H3O4P
Molgewicht:
717.631
MOL-Datei:
89697-78-9.mol

Polyhexamethyleneguanidine phosphate Eigenschaften

Sicherheit

Polyhexamethyleneguanidine phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Polyhexamethyleneguanidine phosphate (PHMG-P) has been widely used as a disinfectant because of its strong bactericidal activity and low toxicity.

Toxicity evaluation

Administration of PHMG-P induced proinflammatory cytokines elevation and infiltration of immune cells into the lungs. Histopathological analysis revealed a dose-dependent exacerbation of both inflammation and pulmonary fibrosis on day 14. PHMG-P also decreased the total cell number and the CD4+/CD8+ cell ratio in the thymus, with the histopathological examination indicating severe reduction of cortex and medulla. The mRNA levels of biomarkers associated with T cell development also decreased markedly. These findings suggest that exposure of lung tissue to PHMG-P leads to pulmonary inflammation and fibrosis as well as thymic atrophy.

Polyhexamethyleneguanidine phosphate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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