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Diazoxid Produkt Beschreibung

Englisch Name:

Diazoxid Eigenschaften

1.3767 (rough estimate)
1.6300 (estimate)
storage temp. 
Store at RT
0.1 M NaOH: soluble
pKa 8.5 (Uncertain)
Soluble in 0.1M NaOH. Insoluble in water or in methanol.
maximale Wellenlänge (λmax)
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38
S-Sätze: 22-26-36
WGK Germany  3
RTECS-Nr. DK8185000
HS Code  2934990002
Bildanzeige (GHS)
Alarmwort Warnung
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Diazoxid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Solid


wound healing agent


Diazoxide reduces status epilepticus neuron damage in diabetes.


ChEBI: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the oncentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.


Hyperstat (Schering); Proglycem (Baker Norton).

Biologische Funktion

Diazoxide (Hyperstat) is chemically similar to the thiazide diuretics. It is devoid of diuretic activity and causes Na+ and water retention. Diazoxide is a very potent vasodilator and is available only for intravenous use in the treatment of hypertensive emergencies. The mechanism by which diazoxide relaxes vascular smooth muscle is related to its ability to activate potassium channels and produce a hyperpolarization of the cell membrane.

Allgemeine Beschreibung

Diazoxide is 7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide , and is currentlyavailable in the United States only as a 50-mg/mLoral suspension (Proglycem); discontinued formulations includedcapsules for oral administration, and injectable formsthat typically found use for indications other than hypoglycemicconditions. Diazoxide is a cyclic benzenesulfonamide,although the free acid in solution can exist in threetautomeric forms, and the 4H tautomer most likely predominatesto a very high proportion. Partly because of theadditional nitrogen in the quinazoline ring structure, themolecule is somewhat more acidic (pKa~8.4, 8.6)than benzenesulfonamide (pKa~10).

Allgemeine Beschreibung

Diazoxide is used as the sodium salt of7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide(Hyperstat IV). Diazoxide lowers peripheral vascular resistance,increases cardiac output, and does not compromiserenal blood flow.
This is a des-sulfamoyl analog of the benzothiazine diureticsand has a close structural similarity to chlorothiazide. Itwas developed intentionally to increase the antihypertensiveaction of the thiazides and to minimize the diuretic effect.

Biologische Aktivität

Antihypertensive, activates ATP-dependent K + channels. Induces activation of PKC ε , an intermediate in the opening of mitoK ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.


The hemodynamic effects of diazoxide are similar to those of hydralazine and minoxidil. It produces direct relaxation of arteriolar smooth muscle with little effect on capacitance beds. Since it does not impair cardiovascular reflexes, orthostasis is not a problem. Its administration is, however, associated with a reflex increase in cardiac output that partially counters its antihypertensive effects. Propranolol and other -blockers potentiate the vasodilating properties of the drug. Diazoxide has no direct action on the heart. Although renal blood flow and glomerular filtration may fall transiently, they generally return to predrug levels within an hour.

Clinical Use

Diazoxide is used by intravenous injection as a rapidly acting antihypertensiveagent for emergency reduction of blood pressurein hospitalized patients with accelerated or malignanthypertension. More than 90% is bound to serum protein, andcaution is needed when it is used in conjunction with otherprotein-bound drugs that may be displaced by diazoxide.The injection is given rapidly by the intravenous route toensure maximal effect. The initial dose is usually 1 mg/kg ofbody weight, with a second dose given if the first injectiondoes not lower blood pressure satisfactorily within 30 minutes.Further doses may be given at 4- to 24-hour intervalsif needed. Oral antihypertensive therapy is begun as soon aspossible.

Clinical Use

In contrast to the acute clinical uses of glucagon, diazoxidefinds use in chronic hypoglycemic conditions: inoperableislet cell adenoma or carcinomas, extrapancreatic malignanciesof insulin-secreting cells, or islet cell hyperplasias. Inchildren, additional indications include congenital hyperinsulinemia124and leucine sensitivity. Experimentally, diazoxideis among an array of ATP-sensitive potassium channel openersbeing studied for intermittently bringing aboutβ-cell rest.


Since diazoxide is not often used for long-term treatment, toxicities associated with chronic use are rare.The chief concern is the side effects associated with the increased workload on the heart, which may precipitate myocardial ischemia and Na+ and water retention. These undesirable effects can be controlled by concurrent therapy with a β-blocker and a diuretic.
Diazoxide may cause hyperglycemia, especially in diabetics, so if the drug is used for several days, blood glucose levels should be measured. When used in the treatment of toxemia, diazoxide may stop labor, because it relaxes uterine smooth muscle.

Veterinary Drugs and Treatments

Oral diazoxide is used in canine and ferret medicine for the treatment of hypoglycemia secondary to hyperinsulin secretion (e.g., insulinoma). Insulinomas are apparently very rare in the cat; there is little experience with this drug in that species.
In human medicine, intravenous diazoxide is sometimes used for treating severe hypertension.


Diazoxide lowers blood pressure within 3 to 5 minutes after rapid intravenous injection, and its duration of action may be 4 to 12 hours. Interestingly, if diazoxide is either injected slowly or infused its hypotensive action is quite modest.This is believed to be due to a rapid and extensive binding of the drug to plasma proteins. Both the liver and kidney contribute to its metabolism and excretion.The plasma half-life is therefore prolonged in patients with chronic renal failure.

Diazoxid Upstream-Materialien And Downstream Produkte


Downstream Produkte

Diazoxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 112)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
career henan chemical co
+86-371-86658258 CHINA 29979 58
hdzhl biotechnology co., ltd
86-13032617415 CHINA 1033 58
Hebei Aicrowe Biotech Co., Ltd
0311-66855331 CHINA 315 58
BOC Sciences
1-631-614-7828 United States 20115 58
Chongqing Chemdad Co., Ltd +86-13650506873 CHINA 30864 58
Shanghai Synmedia Chemical Co., Ltd. +86 (21) 3868-1880
+86 (21) 3390-8196 China 158 58
Shanghai Elestone Pharmaceutical Technology Co., Ltd. 021-36680027/QQ:1762825045; China 296 58
hebei aicrowe co.,ltd 0311-66855331 15533616561
0311-66855331 China 12 58

364-98-7(Diazoxid)Verwandte Suche:

  • DIAZOXIDE 364-98-7 kf-wang(at)
  • Diazoxide API
  • Diazoxided
  • Eudemine
  • hyperstat
  • NSC-64198
  • Sch-6783
  • 7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
  • Diazoxide,7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • Diazoxide (200 mg)
  • 2h-1,2,4-benzothiadiazine,7-chloro-3-methyl-,1,1-dioxide
  • 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1
  • 7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido
  • mutabase
  • proglicem
  • srg95213
  • diazossido
  • dizoxide
  • 7-chloro-3-methyl-4H-1λ,2,4-benzothiadiazine-1,1-dione
  • 7-chloro-3-methyl-4h-1λ6,2,4-benzothiadiazine 1,1-dioxide
  • 364-98-7
  • C8H7ClN2O2S
  • Ion Channels
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Potassium channel
  • Ion Channels
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
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