AA-CW236

AA-CW236 Struktur
1869921-96-9
CAS-Nr.
1869921-96-9
Englisch Name:
AA-CW236
Synonyma:
AA-CW236;AA-CW236 (AA-CW-236;AA-CW236 >=98% (HPLC);1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-
CBNumber:
CB84667476
Summenformel:
C17H16ClF3N4O2
Molgewicht:
400.78
MOL-Datei:
1869921-96-9.mol

AA-CW236 Eigenschaften

Siedepunkt:
535.0±60.0 °C(Predicted)
Dichte
1.43±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Aggregatzustand
powder
pka
-0.37±0.10(Predicted)
Farbe
white to beige

Sicherheit

AA-CW236 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

AA-CW236 has been used as an inhibitor of m6G DNA methyltransferase in mouse embryo fibroblasts.

Biochem/physiol Actions

AA-CW236 is a cell-permeable chloromethyl triazole (CMT) derivative that acts as a non-pseudosubstrate inhibitor against human O(6)-alkylguanine DNA methyltransferase (MGMT) by targeting MGMT active site Cys145 for covalent modification (KI = 24 nM, kinact = 0.03/min), displaying little affinity toward cysteines from other cellular proteins. AA-CW236 pretreatment (1 μM) effectively prevents MGMT from repairing DNA damage, causing significantly more upregulated O6-alkylguanine accumulation than the pseudosubstrate inhibitor Lomeguatrib (1 μM) when co-administered with the DNA-alkylating agent Temozolomide/TMZ (300 μM) in MCF-7 cells. Likewise, AA-CW236 is shown to boost TMZ toxicity in Caco-2 cultures (IC50 = 227 and 673 μM, respectively, with or without 3 μM AA-CW236 co-treatment).

AA-CW236 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AA-CW236 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
DC Chemicals 021-58447131 13564518121
sales@dcchemicals.com China 9414 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24131 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050
cindy.huang@synzest.com China 12007 58

  • AA-CW236
  • AA-CW236 (AA-CW-236
  • 1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-
  • AA-CW236 >=98% (HPLC)
  • 1869921-96-9
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