AA-CW236

CAS No.
1869921-96-9
Chemical Name:
AA-CW236
Synonyms
AA-CW236;AA-CW236 (AA-CW-236;AA-CW236 >=98% (HPLC);1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-
CBNumber:
CB84667476
Molecular Formula:
C17H16ClF3N4O2
Molecular Weight:
400.78
MDL Number:
MFCD30537541
MOL File:
1869921-96-9.mol
MSDS File:
SDS
Last updated:2023-07-14 17:45:26

AA-CW236 Properties

Boiling point 535.0±60.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. 2-8°C
form powder
pka -0.37±0.10(Predicted)
color white to beige

AA-CW236 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1761 AA-CW236 ≥98% (HPLC) 1869921-96-9 25mg $464 2024-03-01 Buy
Sigma-Aldrich SML1761 AA-CW236 ≥98% (HPLC) 1869921-96-9 5mg $107 2023-06-20 Buy
Product number Packaging Price Buy
SML1761 25mg $464 Buy
SML1761 5mg $107 Buy

AA-CW236 Chemical Properties,Uses,Production

Uses

AA-CW236 has been used as an inhibitor of m6G DNA methyltransferase in mouse embryo fibroblasts.

Biochem/physiol Actions

AA-CW236 is a cell-permeable chloromethyl triazole (CMT) derivative that acts as a non-pseudosubstrate inhibitor against human O(6)-alkylguanine DNA methyltransferase (MGMT) by targeting MGMT active site Cys145 for covalent modification (KI = 24 nM, kinact = 0.03/min), displaying little affinity toward cysteines from other cellular proteins. AA-CW236 pretreatment (1 μM) effectively prevents MGMT from repairing DNA damage, causing significantly more upregulated O6-alkylguanine accumulation than the pseudosubstrate inhibitor Lomeguatrib (1 μM) when co-administered with the DNA-alkylating agent Temozolomide/TMZ (300 μM) in MCF-7 cells. Likewise, AA-CW236 is shown to boost TMZ toxicity in Caco-2 cultures (IC50 = 227 and 673 μM, respectively, with or without 3 μM AA-CW236 co-treatment).

AA-CW236 Preparation Products And Raw materials

Raw materials

Preparation Products

AA-CW236 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
AA-CW236 AA-CW236 (AA-CW-236 1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]- AA-CW236 >=98% (HPLC) 1869921-96-9