THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

251310-57-3

CAS-Nr.: 251310-57-3

Englisch Name:: THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

Synonyma:: TR ANTAGONIST 1-850;THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide

CBNumber:: CB8468369

Summenformel:: C21H20F3N5O4

Molgewicht:: 463.41

MOL-Datei:: Mol file

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 14

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Eigenschaften

Dichte: 1.464±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: ≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide

Aggregatzustand: crystalline solid

pka: 9.75±0.43(Predicted)

Sicherheit

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC₅₀s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 14)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Shanghai Universal Biotech Co.,Ltd	18768175414	gaojun@univ-bio.com	China	24998	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5141	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Shanghai Lingfei Pharmaceutical Technology Co., Ltd	15618928656 15618928656	771909552@qq.com	China	1005	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
TR ANTAGONIST 1-850
2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE
1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea
Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
251310-57-3
C21H20F3N5O4