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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Struktur
338967-87-6
CAS-Nr.
338967-87-6
Englisch Name:
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Synonyma:
Mdivi 1;4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-;Mdivi;CS-951;Mdivi1/Mdivi-1;Mdivi-1, 338967-87-6;Mitochondrial division inhibitor 1;Mitochondrial Division Inhibitor, mdivi-1;Mdivi-1 (Mitochondrial division inhibitor 1);MDIVI 1;MDIVI1;MITOCHONDRIAL DIVISION INHIBITOR 1
CBNumber:
CB92518885
Summenformel:
C15H10Cl2N2O2S
Molgewicht:
353.22
MOL-Datei:
338967-87-6.mol
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Eigenschaften

Schmelzpunkt:
289 °C
Siedepunkt:
522.5±60.0 °C(Predicted)
Dichte
1.57±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: >20mg/mL
Aggregatzustand
White solid
pka
9.91±0.20(Predicted)
Farbe
White
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2933.59.8000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1; IC50 = ~1-10 μM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 μM. Mdivi 1 (50 μM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 μM, respectively. Mdivi 1 (1 μM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.

Verwenden

Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.

Allgemeine Beschreibung

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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338967-87-6()Verwandte Suche:

4-Methoxy-anilin Chlorphenylsilan Phenylsilan Trichlor(phenyl)silan N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid ((3-Chlorphenyl)hydrazono)-malanonitril ((4-Trifluormethoxy)phenyl)-hydrazono)malononitril
  • 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
  • Mdivi1/Mdivi-1
  • Mitochondrial division inhibitor 1
  • 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE EXACT
  • Mitochondrial Division Inhibitor, mdivi-1
  • 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1
  • Mitochondrial division inhibitor 1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
  • Mdivi-1, 338967-87-6
  • Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
  • CS-951
  • MDIVI 1;MDIVI1;MITOCHONDRIAL DIVISION INHIBITOR 1
  • 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
  • 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone USP/EP/BP
  • Mdivi-1 (Mitochondrial division inhibitor 1)
  • Mdivi
  • Mdivi 1
  • 4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-
  • 3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one
  • Mitochondrial Autophagy,Mitochondrial division inhibitor1,Inhibitor,inhibit,Autophagy,Mitophagy,Mdivi 1,Mdivi1,Mitochondrial division inhibitor-1,Dynamin,Apoptosis,Mdivi-1
  • 338967-87-6
  • C25H10Cl2N2O2S
  • Inhibitors
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