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N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid Produkt Beschreibung

Melatonine Struktur
73-31-4
CAS-Nr.
73-31-4
Bezeichnung:
N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid
Englisch Name:
Melatonine
Synonyma:
MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;MELATONIN;melotonin;MELATONINE
CBNumber:
CB5364927
Summenformel:
C13H16N2O2
Molgewicht:
232.28
MOL-Datei:
73-31-4.mol

N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid Eigenschaften

Schmelzpunkt:
116.5-118 °C (lit.)
Siedepunkt:
374.44°C (rough estimate)
Dichte
1.1099 (rough estimate)
Brechungsindex
1.6450 (estimate)
Flammpunkt:
9℃
storage temp. 
-20°C
Löslichkeit
Soluble in ethanol to at least 50mg/ml
pka
16.26±0.46(Predicted)
Aggregatzustand
Powder
Farbe
white to off-white
Merck 
14,5816
BRN 
205542
InChIKey
DRLFMBDRBRZALE-UHFFFAOYSA-N
CAS Datenbank
73-31-4(CAS DataBase Reference)
NIST chemische Informationen
Melatonin(73-31-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,F
R-Sätze: 60-39/23/24/25-23/24/25-11
S-Sätze: 24/25-99-53-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS-Nr. AC5955000
8-10-23
HS Code  29379000
Giftige Stoffe Daten 73-31-4(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: > 3200 mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Melatonin, at times referred to as the “hormone of darkness,” normally is secreted during the night. It is synthesized in the pineal gland, and its secretion is controlled by the suprachiasmatic nucleus, following an endogenous circadian rhythm. Studies indicate that melatonin may

Chemische Eigenschaften

Off-White Powder

Occurrence

Melatonin is a naturally occurring hormone in the body.

Verwenden

Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase

Verwenden

Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger

Verwenden

Immunostimulant;Melatonin receptor ligand

Verwenden

Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

Definition

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.

Weltgesundheitsorganisation (WHO)

Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.

Biologische Aktivität

Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .

Clinical Use

Melatonin is most effective in young individuals and appears to be less effective in elderly individuals (possibly because of a decreased number of receptors). Melatonin causes a phase shift of approximately 1 hour per day. This means that the use of melatonin in the morning can delay the onset of evening sleepiness, whereas melatonin taken in the evening has been associated with faster onset of sleep and increased total sleep time. Melatonin is sold as a food supplement in the United States, but it has become popular for use as a hypnotic and for alleviating jet lag (a flight across five or more time zones) and helping to resynchronize individuals who have difficulty adapting to night-shift work. have effects on circadian rhythm and sleep processes. The presence of a pharmacologically specific receptor for melatonin in which the molecular structure is known are referred to as MT1, MT2, and MT3 receptors. The MT1 and MT2 receptors are high-affinity G protein coupled receptors, whereas MT3 is a form of quinone reductase. The MT1 receptor appears to be primarily involved in initiating sleep, whereas the MT2 receptor appears to mediate melatonins effect in the eye, circadian rhythm, and vascular effects. The importance of MT3, although widely distributed in different tissues, is currently unknown. The normal physiological concentration of melatonin observed at night is approximately 100 to 200 pg/mL, and oral doses of 0.1 to 0.3 mg of melatonin are adequate to obtain these concentrations even though melatonin frequently is given at doses of 1 to 10 mg to obtain supraphysiological levels. These higher doses may be the reason for some of the side effects not currently associated with the melatonin receptors.

Veterinary Drugs and Treatments

Melatonin may be useful to treat Alopecia-X in Nordic breeds, canine pattern baldness, or canine recurrent flank alopecia in dogs. It has been used anecdotally for the treatment of sleep cycle disorders in cats and geriatric dogs and to treat phobias and separation anxiety in dogs. Melatonin implants are used in the mink and fox pelt industries to promote the development of luxurious hair coats. Implants are also used to improve early breeding and ovulation rates in sheep and goats. Preliminary research is being done for this purpose in horses also.
In pigs, one study (Bubenik, Ayles et al. 1998) demonstrated that 5 mg/kg in feed reduced the incidence of gastric ulcers in young pigs.

N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 615)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com CHINA 1598 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 192 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
Hangzhou Cherry Pharmaceutical Technology Co.,ltd
0571-81636070
0571-81636070 info@cherrypharmatech.com CHINA 199 58
Hebei Lvyang Biotechnology Co.,Ltd
15030198922 +86 15030198922
0311-68052281 manager@ly-biotech.com CHINA 86 58
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 2703 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1218 58
Baoji Guokang Bio-Technology Co., Ltd.
09173909592
09173909592 cngksw@aliyun.com CHINA 9446 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55

73-31-4(N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid)Verwandte Suche:


  • Melatonin (AS)
  • Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide
  • MELATONINE FOR SYNTHESIS 1 G
  • MELATONINE FOR SYNTHESIS 5 G
  • Melatonin solution
  • N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
  • N-(2-(5-methoxyindol-3-yl)ethyl)acetamide
  • MLT
  • Melatonin 0.25
  • Melatonine Synonyms N-(2-(5-methoxyindol-3-yl)ethyl)acetamide
  • N-ACETYL-5-METHOXYTRYPTAMINE
  • MELATONINE
  • MELATONIN
  • 3-(N-ACETYL-2-AMINOETHYL)-5-METHOXYINDOLE
  • 5-METHOXY-N-ACETYLTRYPTAMINE
  • ACETYL-5-METHOXYTRYPTAMINE
  • AKOS BB-4935
  • Melatonin 73-31-4
  • TIMTEC-BB SBB003265
  • JACS-73-31-4
  • Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-
  • Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-
  • Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl]
  • Melatonin(N-Acetyl-5-methoxytryptamine)
  • 3-N-Acetyl-5-methoxyl tryptamine
  • MELATONIN, 99.5+%
  • MELATONIN F&D VERSION FOR VETERINARY US
  • MELATONIN CRYSTALLINE
  • MELATONIN,(SECONDARY STANDARD)
  • MELATONIN,(PRIMARY STANDARD)
  • MELATONIN, HPLC ANALYSIS KIT
  • MELATONIN,1.0MG/MLINMETHANOL
  • MELATONIN,POWDER
  • N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ethanamide
  • MELATONIN (MLT)
  • primex
  • N-Acetyl-5-Methoxytryptamine also Melatonine
  • pharmaceutical grade Melatonin
  • Melatonin 99.0%min
  • Circadin
  • Melovine
  • Melatonin ,99%
  • 3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole
  • N-Acetyl-5-methoxytriptamine
  • MELATONIN (M)
  • Melatonine,99%
  • Melatonin ,98%
  • Melatonin (100 mg) (AS)
  • MLK7
  • mlklak
  • ZAK, active, GST tagged human
  • Anti-Malt1 antibody produced in goat
  • MLT1
  • mucosa associated lymphoid tissue lymphoma translocation gene 1
  • Melatonin (150 mg)
  • Melatonin standard substance
  • melotonin
  • n-(2-(5-methoxy-1h-indol-3-yl)ethyl)-acetamid
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